This paper describes an action framework for countries with low tuberculosis (TB) incidence
(<100 TB cases per million population) that are striving for TB elimination. The framework …

Background The Xpert MTB/RIF assay is an automated molecular test that has improved the
detection of tuberculosis and rifampicin resistance, but its sensitivity is inadequate in …

The Xpert MTB/RIF assay (Xpert) is a rapid test for tuberculosis (TB) and rifampin resistance
(RIF-R) suitable for point-of-care testing. However, it has decreased sensitivity in smear-…

Extrapulmonary tuberculosis (EPTB) accounts for more than 20% of tuberculosis (TB) cases.
Xpert MTB/RIF (Xpert) (Cepheid, Sunnyvale, CA, USA) is a fully automated amplification …

If tuberculosis (TB) is to be eliminated as a global health problem in the foreseeable future,
improved detection of patients, earlier diagnosis and timely identification of rifampicin …

A clear understanding of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis
is required to accelerate the development of rapid drug susceptibility testing methods …

Whole genome sequencing (WGS) of Mycobacterium tuberculosis has rapidly progressed
from a research tool to a clinical application for the diagnosis and management of tuberculosis …

Considerable effort has been directed toward controlling tuberculosis, which kills almost two
million people yearly. High on the research agenda is the discovery of biomarkers of active …

Antibiotic-resistant tuberculosis poses a global threat, causing the deaths of hundreds of
thousands of people annually. While whole-genome sequencing (WGS), with its unprecedented …

The European Centre for Disease Prevention and Control (ECDC) and the European
Respiratory Society (ERS) jointly developed European Union Standards for Tuberculosis Care (…