User profiles for Danen Cunoosamy
Danen CunoosamySanofi USA Verified email at sanofi.com Cited by 1082 |
[HTML][HTML] Use of precision cut lung slices as a translational model for the study of lung biology
G Liu, C Betts, DM Cunoosamy, PM Åberg… - Respiratory …, 2019 - Springer
Animal models remain invaluable for study of respiratory diseases, however, translation of
data generated in genetically homogeneous animals housed in a clean and well-controlled …
data generated in genetically homogeneous animals housed in a clean and well-controlled …
The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation
Fine control of macrophage activation is needed to prevent inflammatory disease, particularly
at barrier sites such as the lungs. However, the dominant mechanisms that regulate the …
at barrier sites such as the lungs. However, the dominant mechanisms that regulate the …
[HTML][HTML] Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA)
…, G Brusselle, GW Clarke, D Cunoosamy… - European …, 2023 - Eur Respiratory Soc
Background Effectiveness studies with biological therapies for asthma lack standardised
outcome measures. The COMSA (Core Outcome Measures sets for paediatric and adult Severe …
outcome measures. The COMSA (Core Outcome Measures sets for paediatric and adult Severe …
Role of B cell–activating factor in chronic obstructive pulmonary disease
…, A Schinwald, H Hammad, DM Cunoosamy… - American journal of …, 2015 - atsjournals.org
Rationale: B cell–activating factor (BAFF) plays a major role in activation of B cells and in
adaptive humoral immune responses. In chronic obstructive pulmonary disease (COPD), …
adaptive humoral immune responses. In chronic obstructive pulmonary disease (COPD), …
Role of CXCL13 in Cigarette Smoke–induced Lymphoid Follicle Formation and Chronic Obstructive Pulmonary Disease
…, C Bantsimba-Malanda, DM Cunoosamy… - American journal of …, 2013 - atsjournals.org
Rationale: The B cell–attracting chemokine CXCL13 is an important mediator in the formation
of tertiary lymphoid organs (TLOs). Increased numbers of ectopic lymphoid follicles have …
of tertiary lymphoid organs (TLOs). Increased numbers of ectopic lymphoid follicles have …
Dynamics of IFN-β responses during respiratory viral infection. Insights for therapeutic strategies
Rationale: Viral infections are major drivers of exacerbations and clinical burden in patients
with asthma and chronic obstructive pulmonary disease (COPD). IFN-β is a key component …
with asthma and chronic obstructive pulmonary disease (COPD). IFN-β is a key component …
Design, synthesis, and biological evaluation of MEK PROTACs
S Vollmer, D Cunoosamy, H Lv, H Feng… - Journal of Medicinal …, 2019 - ACS Publications
PROteolysis TArgeting Chimeras (PROTACs) targeting the degradation of MEK have been
designed based on allosteric MEK inhibitors. Inhibition of the phosphorylation of ERK1/2 was …
designed based on allosteric MEK inhibitors. Inhibition of the phosphorylation of ERK1/2 was …
The development of AZD7624 for prevention of exacerbations in COPD: a randomized controlled trial
NR Patel, DM Cunoosamy, M Fagerås… - … journal of chronic …, 2018 - Taylor & Francis
Background p38 mitogen-activated protein kinase (MAPK) plays a central role in the regulation
and activation of pro-inflammatory mediators. COPD patients have increased levels of …
and activation of pro-inflammatory mediators. COPD patients have increased levels of …
A disintegrin and metalloproteinase domain-8: a novel protective proteinase in chronic obstructive pulmonary disease
…, V Pinto-Plata, LM Sholl, D Cunoosamy… - American journal of …, 2018 - atsjournals.org
Rationale: ADAM8 (a disintegrin and metalloproteinase domain-8) is expressed by leukocytes
and epithelial cells in health, but its contribution to the pathogenesis of chronic obstructive …
and epithelial cells in health, but its contribution to the pathogenesis of chronic obstructive …
Human lung conventional dendritic cells orchestrate lymphoid neogenesis during chronic obstructive pulmonary disease
…, F Melville, KJ Staples, DM Cunoosamy… - American journal of …, 2020 - atsjournals.org
Rationale: Emerging evidence supports a crucial role for tertiary lymphoid organs (TLOs) in
chronic obstructive pulmonary disease (COPD) progression. However, mechanisms of …
chronic obstructive pulmonary disease (COPD) progression. However, mechanisms of …