Two-, six-, and 12-minute walking tests in respiratory disease.

…, ER Gross, AA Woodcock, DM Geddes - … (Clinical research ed …, 1982 - ncbi.nlm.nih.gov
… We studied 11 non-insulin dependent and 10 insulin-dependent patients with diabetes
mellitus. Each group was randomised to the control or trial diet. The control low-fibre diet was a …

Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis

…, L Huang, DJ Porteous, R Williamson, DM Geddes - Nature medicine, 1995 - nature.com
We report the results of a double-blind, placebo-controlled trial in nine cystic fibrosis (CF)
subjects receiving cationic liposome complexed with a complementary DNA encoding the CF …

[HTML][HTML] Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial

…, J Gavino, S Gea-Sorli, DM Geddes… - The Lancet …, 2015 - thelancet.com
Background Lung delivery of plasmid DNA encoding the CFTR gene complexed with a
cationic liposome is a potential treatment option for patients with cystic fibrosis. We aimed to …

Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial

…, SH Cheng, AE Smith, D Meeker, DM Geddes - The Lancet, 1999 - thelancet.com
Background We and others have previously reported significant changes in chloride transport
after cationic-lipid-mediated transfer of the cystic fibrosis transmembrane conductance …

Bronchoscopic volume reduction with valve implants in patients with severe emphysema.

…, C Morgan, PG Goldstraw, MI Polkey, DM Geddes - The Lancet, 2003 - thelancet.com
… T Toma and D Geddes received an honararium for time spent attending two FDA meetings
in Washington DC, USA, to discuss research protocols with the Emphasys valve system. T …

Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice

…, DM Steel, FM Munkonge, PK Jeffery, DM Geddes… - Nature …, 1993 - nature.com
We report gene transfer to the Edinburgh insertional mutant mouse (cf/cf), delivering CFTR
cDNA–liposome complexes into the airways by nebulization. We show full restoration of …

Effect of bronchoscopic lung volume reduction on dynamic hyperinflation and exercise in emphysema

…, P Goldstraw, J Moxham, DM Geddes… - American journal of …, 2005 - atsjournals.org
Endobronchial valve placement improves pulmonary function in some patients with chronic
obstructive pulmonary disease, but its effects on exercise physiology have not been …

Bronchoscopic lung volume reduction for end-stage emphysema: report on the first 98 patients

IYP Wan, TP Toma, DM Geddes, G Snell, T Williams… - Chest, 2006 - Elsevier
Objectives: To report the first multicenter experience on the treatment of end-stage emphysema
using an endobronchial valve (EBV) [Emphasys EBV; Emphasys Medical; Redwood City, …

Progressive airway obliteration in adults and its association with rheumatoid disease

DM GEDDES, B CORRIN, DA Brewerton… - … Journal of Medicine, 1977 - academic.oup.com
Six patients with rapidly progressive airway obliteration in the absence of chronic bronchitis
or emphysema are reported. Because this pattern of lung disease is very uncommon and …

Cystic fibrosis in the mouse by targeted insertional mutagenesis

…, P Dickinson, EWFW Alton, SN Smith, DM Geddes… - Nature, 1992 - nature.com
Cystic flbrosis is a fatal genetic disorder which afflicts 50,000 people worldwide. A viable
animal model would be invaluable for investigating and combating this disease. The mouse …