Salmonella pathogenicity island 2 (SPI‐2) encodes a putative type III secretion system necessary
for systemic infection in animals. We have investigated the transcriptional organization …

Tuberculosis control relies on the identification and preventive treatment of individuals who
are latently infected with Mycobacterium tuberculosis. However, direct identification of latent …

This paper describes an action framework for countries with low tuberculosis (TB) incidence
(<100 TB cases per million population) that are striving for TB elimination. The framework …

Background The Xpert MTB/RIF assay is an automated molecular test that has improved the
detection of tuberculosis and rifampicin resistance, but its sensitivity is inadequate in …

The Xpert MTB/RIF assay (Xpert) is a rapid test for tuberculosis (TB) and rifampin resistance
(RIF-R) suitable for point-of-care testing. However, it has decreased sensitivity in smear-…

… Lange and DM Cirillo) and agreement by the TBNET steering committee, co-authors were
invited from among international experts in the field of MDR/XDR-TB (chapter leaders and …

Extrapulmonary tuberculosis (EPTB) accounts for more than 20% of tuberculosis (TB) cases.
Xpert MTB/RIF (Xpert) (Cepheid, Sunnyvale, CA, USA) is a fully automated amplification …

A clear understanding of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis
is required to accelerate the development of rapid drug susceptibility testing methods …

Generalist and specialist species differ in the breadth of their ecological niches. Little is known
about the niche width of obligate human pathogens. Here we analyzed a global collection …

Considerable effort has been directed toward controlling tuberculosis, which kills almost two
million people yearly. High on the research agenda is the discovery of biomarkers of active …