Some surveys have shown that the intended users are sometimes unaware of the existence
of guidelines, or simply do not translate them into practice. Thus, implementation …

Background Current guidelines suggest that, for patients at moderate risk of death from
unstable coronary-artery disease, either an interventional strategy (angiography followed by …

Background The long-term outcome of an interventional strategy in patients with non-ST-elevation
acute coronary syndrome is unknown. We tested whether an interventional strategy (…

Background. Patients undergoing heartvalve replacement may receive a mechanical
prosthesis, necessitating lifelong anticoagulant treatment, or a porcine bioprosthesis, which …

Objective: To compare survival and outcome in patients receiving a mechanical or bioprosthetic
heart valve prosthesis. Design: Randomised prospective trial. Setting: Tertiary cardiac …

… El-Fiky MM, Taggart DP, Carter R, Stockwell MC, Made BH, Wheatley DJ. Respiratory
dysfunction following cardiopulmonary bypass: verification of a non-invasive technique to measure …

… Wilkinson, TG Mackay, and DJ Wheatley, ‘‘Calcification and stress distribution in bovine …
GM Bernacca, AC Fisher, TG Mackay, and DJ Wheatley, ‘‘A dynamic in vitro method for studying …

Objectives: The prospects for a durable, athrombogenic, synthetic, flexible leaflet heart valve
are enhanced by the recent availability of novel, biostable polyurethanes. As a forerunner to …

OBJECTIVE To evaluate the effectiveness of a nurse led shared care programme to improve
coronary heart disease risk factor levels and general health status and to reduce anxiety …

In light of the thrombogenicity of mechanical valves and the limited durability of bioprosthetic
valves, alternative designs and materials are being considered for prosthetic heart valves. A …