Receptor–ligand binding assays: technologies and applications

LAA De Jong, DRA Uges, JP Franke… - Journal of chromatography …, 2005 - Elsevier
Receptor–ligand interactions play a crucial role in biological systems and their measurement
forms an important part of modern pharmaceutical development. Numerous assay formats …

The relationship between benzodiazepine use and traffic accidents: a systematic literature review

BE Smink, ACG Egberts, KJ Lusthof, DRA Uges… - CNS drugs, 2010 - Springer
In many countries, benzodiazepines are the most commonly used and misused psychoactive
medicinal drugs. Results of epidemiological studies investigating the association between …

Genetic factors influencing pyrimidine-antagonist chemotherapy

…, HJM Groen, FM Wachters, DRA Uges… - The …, 2005 - nature.com
Pyrimidine antagonists, for example, 5-fluorouracil (5-FU), cytarabine (ara-C) and gemcitabine
(dFdC), are widely used in chemotherapy regimes for colorectal, breast, head and neck, …

Electrochemical and surface characterization of a nickel–titanium alloy

…, AG Veldhuizen, J De Vries, HJ Busscher, DRA Uges… - Biomaterials, 1998 - Elsevier
For clinical implantation purposes of shape memory metals the nearly equiatomic nickel–titanium
(NiTi) alloy is generally used. In this study, the corrosion properties and surface …

Surface roughness, porosity and wettability of gentamicin-loaded bone cements and their antibiotic release

H Van de Belt, D Neut, DRA Uges, W Schenk… - Biomaterials, 2000 - Elsevier
In this study, the release of gentamicin as a function of time was measured for six different
gentamicin-loaded bone cements and related with the surface roughness, porosity and …

Circulating plasma platinum more than 10 years after cisplatin treatment for testicular cancer

…, J Messerschmidt, T Gelevert, F Alt, DRA Uges… - The Lancet, 2000 - thelancet.com
We have shown in patients cured from metastatic testicular cancer that up to 20 years after
administration of cisplatincontaining chemotherapy, circulating platinum is still detectable in …

Determination of moxifloxacin in dried blood spots using LC–MS/MS and the impact of the hematocrit and blood volume

…, JWC Alffenaar, J Brouwers, DRA Uges - … of Chromatography B, 2011 - Elsevier
Moxifloxacin (MFX) is a potential oral agent use in the treatment of multidrug-resistance
tuberculosis (MDR-TB). Due to variability in pharmacokinetics and in vitro susceptibility of …

Robust, high-throughput LC-MS/MS method for therapeutic drug monitoring of cyclosporine, tacrolimus, everolimus, and sirolimus in whole blood

RA Koster, ECF Dijkers, DRA Uges - Therapeutic drug monitoring, 2009 - journals.lww.com
The authors describe a fast, robust, and straightforward liquid chromatography and tandem
mass spectrometry (LC-MS/MS) method with the use of a single LC-MS/MS system for …

Fast LC-MS/MS analysis of tacrolimus, sirolimus, everolimus and cyclosporin A in dried blood spots and the influence of the hematocrit and immunosuppressant …

RA Koster, JWC Alffenaar, B Greijdanus, DRA Uges - Talanta, 2013 - Elsevier
We developed a method for the analysis of four immunosuppressants in dried blood spot (DBS)
samples to facilitate therapeutic drug monitoring for transplant patients outside the …

Pharmacokinetics of vincristine in children and adolescents with acute lymphocytic leukemia

WR Crom, SSN de Graaf, T Synold, DRA Uges… - The Journal of …, 1994 - Elsevier
We studied the pharmacokinetics of vincristine in children with acute lymphocytic leukemia
by means of a specific high-performance liquid chromatographic assay with ultraviolet and …