User profiles for D. Le

Albert de la Chapelle

- Verified email at osumc.edu - Cited by 115227

Dung Le

- Verified email at jhmi.edu - Cited by 44630

Donald Les

- Verified email at uconn.edu - Cited by 11402

[HTML][HTML] PD-1 blockade in tumors with mismatch-repair deficiency

…, RM Goldberg, A De La Chapelle… - … England Journal of …, 2015 - Mass Medical Soc
Background Somatic mutations have the potential to encode “non-self” immunogenic antigens.
We hypothesized that tumors with a large number of somatic mutations due to mismatch-…

[HTML][HTML] Pembrolizumab in microsatellite-instability–high advanced colorectal cancer

…, P Gibbs, C de la Fouchardiere… - … England Journal of …, 2020 - Mass Medical Soc
Background Programmed death 1 (PD-1) blockade has clinical benefit in microsatellite-instability–high
(MSI-H) or mismatch-repair–deficient (dMMR) tumors after previous therapy. The …

2019 Global NAFLD prevalence: a systematic review and meta-analysis

…, H Yang, Y Yang, R Jin, RHX Le, Y Xu, DM Le… - Clinical …, 2022 - Elsevier
Background & Aims The increasing rates of obesity and type 2 diabetes mellitus may lead to
increased prevalence of nonalcoholic fatty liver disease (NAFLD). We aimed to determine …

New insecticides with ecdysteroidal and juvenile hormone activity

TS Dhadialla, GR Carlson, DP Le - Annual review of entomology, 1998 - annualreviews.org
Le tébufénozide, un nouveau produit sélectif de lutte contre le carpocapse Cydia
pomonella L. et la tordeuse de la pelure Adoxophyes orana FvR Rev. Suisse Vitic. Arboric. …

Microsatellite instability as a biomarker for PD-1 blockade

JC Dudley, MT Lin, DT Le, JR Eshleman - Clinical Cancer Research, 2016 - AACR
Initial results by Le and colleagues, which were published in the June 25, 2015 issue of the
New England Journal of Medicine, report significant responses of cancers with microsatellite …

Pembrolizumab versus chemotherapy for microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer (KEYNOTE-177): final analysis of a …

…, C de la Fourchardiere, F Rivera, E Elez, DT Le… - The Lancet …, 2022 - thelancet.com
Background Pembrolizumab has shown improved progression-free survival versus
chemotherapy in patients with newly diagnosed microsatellite instability-high or mismatch repair-…

Pembrolizumab versus chemotherapy for microsatellite instability-high/mismatch repair deficient metastatic colorectal cancer: The phase 3 KEYNOTE-177 Study.

…, M Benavides, P Gibbs, C De La Fouchardiere… - 2020 - ascopubs.org
LBA4 Background: KEYNOTE-177 (NCT02563002) is a phase 3, randomized open-label
study evaluating the efficacy and safety of pembrolizumab (pembro) versus standard of care …

Detection of circulating tumor DNA in early-and late-stage human malignancies

…, CC Lee, LA Fecher, GL Gallia, P Gibbs, D Le… - Science translational …, 2014 - science.org
The development of noninvasive methods to detect and monitor tumors continues to be a
major challenge in oncology. We used digital polymerase chain reaction–based technologies …

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

…, JR Eshleman, B Vogelstein, RA Anders, LA Diaz Jr - Science, 2017 - science.org
The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of
somatic mutations. In a proof-of-concept study, we previously showed that colorectal …

DrugBank 5.0: a major update to the DrugBank database for 2018

…, A Wilson, L Chin, R Cummings, D Le… - Nucleic acids …, 2018 - academic.oup.com
DrugBank ( www.drugbank.ca ) is a web-enabled database containing comprehensive
molecular information about drugs, their mechanisms, their interactions and their targets. First …