Resveratrol impairs the release of steroid-resistant inflammatory cytokines from human airway smooth muscle cells in chronic obstructive pulmonary disease
J Knobloch, B Sibbing, D Jungck, Y Lin, K Urban… - … of Pharmacology and …, 2010 - ASPET
Chronic obstructive pulmonary disease (COPD) therapy is complicated by corticosteroid
resistance of the interleukin 8 (IL-8)-dependent and granulocyte macrophage-colony stimulating …
resistance of the interleukin 8 (IL-8)-dependent and granulocyte macrophage-colony stimulating …
The T-helper cell type 1 immune response to gram-negative bacterial infections is impaired in COPD
J Knobloch, K Schild, D Jungck, K Urban… - American journal of …, 2011 - atsjournals.org
Rationale: The increased susceptibility to bacterial infections in chronic obstructive pulmonary
disease (COPD) is critical for exacerbations. Toll-like receptor-4 (TLR4) detects bacteria …
disease (COPD) is critical for exacerbations. Toll-like receptor-4 (TLR4) detects bacteria …
Resveratrol attenuates the release of inflammatory cytokines from human bronchial smooth muscle cells exposed to lipoteichoic acid in chronic obstructive pulmonary …
…, C Wahl, M Feldmann, D Jungck… - Basic & clinical …, 2014 - Wiley Online Library
… 2D). Both resveratrol and dexamethasone did not modulate baseline release of GM-CSF
from HASMCs of patients with COPD (data not shown). Resveratrol and dexamethasone almost …
from HASMCs of patients with COPD (data not shown). Resveratrol and dexamethasone almost …
The molecular mechanisms of thalidomide teratogenicity and implications for modern medicine
J Knobloch, D Jungck, A Koch - Current molecular medicine, 2017 - ingentaconnect.com
Thalidomide is a teratogen that affects many organs but primarily induces limb truncations
like phocomelia. Rodents are thalidomide resistant. In the 1950s, this has led to …
like phocomelia. Rodents are thalidomide resistant. In the 1950s, this has led to …
Resveratrol impairs the release of steroid‐resistant cytokines from bacterial endotoxin‐exposed alveolar macrophages in chronic obstructive pulmonary disease
J Knobloch, H Hag, D Jungck… - Basic & clinical …, 2011 - Wiley Online Library
Airway inflammation in chronic obstructive pulmonary disease (COPD) is believed to be
insensitive to corticosteroids. However, corticosteroids are recommended in COPD (GOLD …
insensitive to corticosteroids. However, corticosteroids are recommended in COPD (GOLD …
Apoptosis induction by thalidomide: critical for limb teratogenicity but therapeutic potential in idiopathic pulmonary fibrosis?
J Knobloch, D Jungck, A Koch - Current molecular …, 2011 - ingentaconnect.com
Thalidomide is a powerful treatment for inflammatory and cancer-based diseases. However,
its clinical use remains limited due to its teratogenic properties, which primarily affect limb …
its clinical use remains limited due to its teratogenic properties, which primarily affect limb …
A systemic defect in Toll-like receptor 4 signaling increases lipopolysaccharide-induced suppression of IL-2-dependent T-cell proliferation in COPD
…, S Yanik, J Rupp, D Jungck… - … of Physiology-Lung …, 2016 - journals.physiology.org
… A–D: IL-2 in cell culture supernatants was analyzed via ELISA at indicated times. C and D:
data from B were correlated by linear regression to FEV 1 (%predicted); r 2 = goodness of fit. E…
data from B were correlated by linear regression to FEV 1 (%predicted); r 2 = goodness of fit. E…
[HTML][HTML] Biomarkers for comorbidities modulate the activity of T-cells in COPD
…, SD Yanik, S Panek, J Kronsbein, D Jungck… - International journal of …, 2021 - mdpi.com
In smoking-induced chronic obstructive pulmonary disease (COPD), various comorbidities
are linked to systemic inflammation and infection-induced exacerbations. The underlying …
are linked to systemic inflammation and infection-induced exacerbations. The underlying …
TNFα-induced GM-CSF release from human airway smooth muscle cells depends on activation of an ET-1 autoregulatory positive feedback mechanism
J Knobloch, H Peters, D Jungck, K Mueller, J Strauch… - Thorax, 2009 - thorax.bmj.com
… D Jungck1, … One-way repeated measures analysis of variance (ANOVA): p<0.0001 (A,
C, D (values for 2 h and 8 h were analysed separately), E, G); p = 0.0001 (B, F). Post hoc …
C, D (values for 2 h and 8 h were analysed separately), E, G); p = 0.0001 (B, F). Post hoc …
TNFα-induced airway smooth muscle cell proliferation depends on endothelin receptor signaling, GM-CSF and IL-6
…, SD Yanik, S Körber, E Stoelben, D Jungck… - Biochemical …, 2016 - Elsevier
… (B, D) After 30 h BrdU was added and after further 18 h the cells were analyzed for BrdU …
2C, D), we assumed that TNFα influences ETBR expression. Indeed, TNFα induced ETBR but …
2C, D), we assumed that TNFα influences ETBR expression. Indeed, TNFα induced ETBR but …