Many patients with chronic pain do not obtain adequate relief or experience unacceptable
side effects from existing treatments. Moreover, even when clinical trials report positive …

The current International Association for the Study of Pain (IASP) definition of pain as “An
unpleasant sensory and emotional experience associated with actual or potential tissue …

Objective. To provide recommendations for the core outcome domains that should be considered
by investigators conducting clinical trials of the efficacy and effectiveness of treatments …

Background In early life, the innate immune system can recognize both viable and nonviable
parts of microorganisms. Immune activation may direct the immune response, thus …

… We wish to acknowledge the nursing efforts of D. Collins and the staff of the General Clinical
Research Centre at the University of Washington and the data management effort of B. Fish. …

Background A farming environment protects against development of asthma, hay fever, and
atopic sensitisation in children. We aimed to establish whether increased exposure to …

… Finally I would like to thank Leslie Carr for her encouragement and support while this book
… d'etre in the discussion of history. Thus the present study, though it hardly qualifies as a story, …

… The present study used a brief, nine-item version of the CES-D that has shown comparable
reliability and validity statistics (Kohut, Berkman, Evans, & Cornoni-Huntley, 1993). …

The underlying pathophysiology of the metabolic syndrome is the subject of debate, with
both insulin resistance and obesity considered as important factors. We evaluated the …

… We do not report these results here, but they are available from the authors or may be found
in Carr et al. (1998). In order to distinguish the time-series contributions to the results, we …