User profiles for D. C. M. Liewald

David CM Liewald

Systems Analyst LBC / CCACE Edinburgh University
Verified email at ed.ac.uk
Cited by 49170

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

…, LJ Launer, B Lehne, T Lehtimäki, DCM Liewald… - Nature …, 2018 - nature.com
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease.
We report the largest genetic association study of blood pressure traits (systolic, diastolic …

Common genetic variants influence human subcortical brain structures

…, AJ Heister, D Hoehn, D Kasperaviciute, DCM Liewald… - Nature, 2015 - nature.com
The highly complex structure of the human brain is strongly shaped by genetic influences 1 .
Subcortical brain regions form circuits with cortical areas to coordinate movement 2 , …

Sex differences in the adult human brain: evidence from 5216 UK biobank participants

…, S Hunter, E Neilson, DCM Liewald… - Cerebral …, 2018 - academic.oup.com
Sex differences in the human brain are of interest for many reasons: for example, there are
sex differences in the observed prevalence of psychiatric disorders and in some …

[HTML][HTML] Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

…, RE Marioni, C Fawns-Ritchie, DCM Liewald… - Nature …, 2018 - nature.com
General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

…, M Larson, LJ Launer, B Lehne, DCM Liewald… - Nature …, 2017 - nature.com
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) …

[HTML][HTML] Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N= 112 151) and 24 GWAS consortia

…, SE Harris, G Davies, WD Hill, DCM Liewald… - Molecular …, 2016 - nature.com
Causes of the well-documented association between low levels of cognitive functioning and
many adverse neuropsychiatric outcomes, poorer physical health and earlier death remain …

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

…, NR Lee, J Lee, J Liao, W Lieb, DCM Liewald… - Nature …, 2015 - nature.com
We carried out a trans-ancestry genome-wide association and replication study of blood
pressure phenotypes among up to 320,251 individuals of East Asian, European and South …

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

…, J Luan, RA Scott, SE Harris, DCM Liewald… - Nature …, 2016 - nature.com
High blood pressure is a major risk factor for cardiovascular disease and premature death.
However, there is limited knowledge on specific causal genes and pathways. To better …

[HTML][HTML] Novel genetic loci associated with hippocampal volume

…, M Klein, B Kraemer, PH Lee, DCM Liewald… - Nature …, 2017 - nature.com
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial
navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal …

[HTML][HTML] Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci

…, B Cullen, D Lyall, SP Hagenaars, DCM Liewald… - Molecular …, 2016 - nature.com
Neuroticism is a personality trait of fundamental importance for psychological well-being and
public health. It is strongly associated with major depressive disorder (MDD) and several …