The immune-privileged status of the central nervous system (CNS) has changed quite
dramatically during the past two decades. Leukocytes have the ability to infiltrate the CNS and …

Macrophages reside in essentially all tissues of the body and play key roles in innate and
adaptive immune responses. Distinct populations of tissue macrophages also acquire context-…

INTRODUCTION Microglia play essential roles in central nervous system homeostasis and
influence diverse aspects of neuronal function, including refinement of synaptic networks and …

As resident macrophages of the CNS, microglia are critical immune effectors of inflammatory
lesions and associated neural dysfunctions. In multiple sclerosis (MS) and its animal models…

Noncoding genetic variation is a major driver of phenotypic diversity, but functional interpretation
is challenging. To better understand common genetic variation associated with brain …

… d, Enhancer reporter assays performed as in b with the indicated luciferase reporters.
Dashed lines represent inversions of the sense or antisense DNA sequence relative to the core …

… (b–d) UCSC Browser images representing normalized RNA-Seq read density from BV2
microglia cell lines transduced with empty vector (control), HTT N548 or mHTT N548 mapped at …

Tissue-resident and recruited macrophages contribute to both host defense and pathology.
Multiple macrophage phenotypes are represented in diseased tissues, but we lack deep …

Macrophages play essential roles in tissue homeostasis, pathogen elimination, and tissue
repair. A defining characteristic of these cells is their ability to efficiently adapt to a variety of …

This paper presents an introduction to independent component analysis (ICA). Unlike
principal component analysis, which is based on the assumptions of uncorrelatedness and …