By the late 1980s, it was clear that allergic diseases, including asthma, eczema, allergic
rhinitis and food allergy, had been increasing in recent decades, but the extent of this increase …

We investigated associations of asthma and smoking with lung function and airway reversibility
from childhood to early adulthood. The population-based Isle of Wight Birth Cohort (n=…

We thank F. Trinkmann and co-authors for their appreciation of our work and also in raising
important questions on the role of small airway function in early detection of lung function …

Much debate surrounds the origins of adolescent wheeze. Using the Isle of Wight Birth Cohort
(IOWBC) we assessed the origins and characteristics of wheeze at 18-years in relation to …

Methods The IOWBC is a population based cohort (n= 1456), recruited in 1989-90 and
assessed at birth, 1, 2, 4, 10, 18 and 26 years for asthma and allergic diseases and …

The influence of early life wheezing phenotype on lung function in young adult wheezers is
unknown. To assess this, the Isle of Wight Birth Cohort (n=1,456) was reviewed at 1, 2, 4, 10 …

It is unclear why some children with persistent wheeze continue wheezing into adulthood
whilst in other subjects wheezing subsides. To assess this the Isle of Wight Birth Cohort (n=…

Introduction: Hypertonic saline (HS) is becoming more established as an aid to physiotherapy
in patients with both non-CF and CF related bronchiectasis(1). This study aimed to review …

Methods The IOWBC is a population based cohort (n= 1456), recruited in 1989-90 and
assessed at birth, 1, 2, 4, 10, 18 and 26 years for asthma and allergic diseases and …

We read with interest the editorial about “Improving palliative care for patients with COPD” [1]
and the subsequent article by Meffet et al. [2]. We would like to highlight the results of our …