The 18 glycosyl hydrolase family of chitinases is an ancient gene family that is widely expressed
from prokaryotes to eukaryotes. In mammals, despite the absence of endogenous chitin, …

Nrf2 regulates expression of genes encoding enzymes with antioxidant (eg. heme oxygenase-1
(HO-1)) or xenobiotic detoxification (eg. NAD(P)H:quinone oxidoreductase, glutathione S…

Members of the 18 glycosyl hydrolase (GH 18) gene family have been conserved over
species and time and are dysregulated in inflammatory, infectious, remodeling, and neoplastic …

Host antibacterial responses include mechanisms that kill bacteria, but also those that
protect or tolerize the host to potentially damaging antibacterial effects. We determined that …

Kidney hypoperfusion during episodes of systemic hypotension or after surgical procurement
for transplantation can lead to tubular cell death via necrosis and apoptosis, which trigger a …

Recent studies demonstrated that chitinase 3-like-1 (Chi3l1) binds to and signals via IL-13Rα2.
However, the mechanism that IL-13Rα2 uses to mediate the effects of Chi3l1 has not …

Vascular endothelial growth factor (VEGF) is a potent stimulator of vascular angiogenesis,
permeability, and remodeling that also plays important roles in wound healing and tissue …

Evasion of the immune response is a hallmark of cancer, and programmed cell death 1 (PD-1)
and PD-1 ligand 1 (PD-L1) are major mediators of this immunosuppression. Chitinase 3–…

… Authorship note: Yang Zhou and Chuan Hua He contributed … Authorship note: Yang Zhou
and Chuan Hua He contributed … Authorship note: Yang Zhou and Chuan Hua He contributed …

Hyperoxic acute lung injury (HALI) is characterized by a cell death response with features of
apoptosis and necrosis that is inhibited by IL-11 and other interventions. We hypothesized …