An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
MPR Berry, CM Graham, FW McNab, Z Xu, SAA Bloch… - Nature, 2010 - nature.com
Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is a major cause of
morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with …
morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with …
[HTML][HTML] Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers
Rationale New approaches to define factors underlying the immunopathogenesis of pulmonary
diseases including sarcoidosis and tuberculosis are needed to develop new treatments …
diseases including sarcoidosis and tuberculosis are needed to develop new treatments …
Enhanced protection to Mycobacterium tuberculosis infection in IL‐10‐deficient mice is accompanied by early and enhanced Th1 responses in the lung
…, A Boonstra, S Read, J Pitt, C Graham… - European journal of …, 2010 - Wiley Online Library
IL‐10 regulates the balance of an immune response between pathogen clearance and
immunopathology. We show here that Mycobacterium tuberculosis (Mtb) infection in the absence …
immunopathology. We show here that Mycobacterium tuberculosis (Mtb) infection in the absence …
[HTML][HTML] Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease [S]
…, S Cain, AE Crunk, A Mansur, CE Graham… - Journal of lipid …, 2013 - ASBMB
The cytoplasmic lipid droplet (CLD) protein perilipin-2 (Plin2) is expressed in multiple
nonadipose tissues, where it is thought to play a role in regulating their lipid storage properties. …
nonadipose tissues, where it is thought to play a role in regulating their lipid storage properties. …
[HTML][HTML] Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy
Rationale Globally there are approximately 9 million new active tuberculosis cases and 1.4
million deaths annually. Effective antituberculosis treatment monitoring is difficult as there are …
million deaths annually. Effective antituberculosis treatment monitoring is difficult as there are …
Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-D-glucose positron emission and computed tomography
…, RP Lai, M Lesosky, KA Wilkinson, CM Graham… - Nature medicine, 2016 - nature.com
Tuberculosis is classically divided into states of latent infection and active disease. Using
combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-…
combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-…
[HTML][HTML] A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection
A Singhania, R Verma, CM Graham, J Lee… - Nature …, 2018 - nature.com
Whole blood transcriptional signatures distinguishing active tuberculosis patients from
asymptomatic latently infected individuals exist. Consensus has not been achieved regarding the …
asymptomatic latently infected individuals exist. Consensus has not been achieved regarding the …
School-aged children's vulnerability to depressive symptomatology: The role of attachment security, maternal depressive symptomatology, and economic risk
CA Graham, MA Easterbrooks - Development and Psychopathology, 2000 - cambridge.org
The influences of three risk factors (insecure attachment, maternal depressive symptoms,
and economic risk) on children's depressive symptomatology were examined. Subjects were …
and economic risk) on children's depressive symptomatology were examined. Subjects were …
Programmed death ligand 1 is over‐expressed by neutrophils in the blood of patients with active tuberculosis
FW McNab, MPR Berry, CM Graham… - European journal of …, 2011 - Wiley Online Library
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the world's
largest infectious disease problems. Despite decades of intensive study, the immune …
largest infectious disease problems. Despite decades of intensive study, the immune …
[HTML][HTML] Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza
…, S Blankley, LT Hoang, M Cox, CM Graham… - Nature …, 2018 - nature.com
Transcriptional profiles and host-response biomarkers are used increasingly to investigate
the severity, subtype and pathogenesis of disease. We now describe whole-blood mRNA …
the severity, subtype and pathogenesis of disease. We now describe whole-blood mRNA …