An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

MPR Berry, CM Graham, FW McNab, Z Xu, SAA Bloch… - Nature, 2010 - nature.com
Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is a major cause of
morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with …

[HTML][HTML] Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers

CI Bloom, CM Graham, MPR Berry, F Rozakeas… - PloS one, 2013 - journals.plos.org
Rationale New approaches to define factors underlying the immunopathogenesis of pulmonary
diseases including sarcoidosis and tuberculosis are needed to develop new treatments …

Enhanced protection to Mycobacterium tuberculosis infection in IL‐10‐deficient mice is accompanied by early and enhanced Th1 responses in the lung

…, A Boonstra, S Read, J Pitt, C Graham… - European journal of …, 2010 - Wiley Online Library
IL‐10 regulates the balance of an immune response between pathogen clearance and
immunopathology. We show here that Mycobacterium tuberculosis (Mtb) infection in the absence …

[HTML][HTML] Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease [S]

…, S Cain, AE Crunk, A Mansur, CE Graham… - Journal of lipid …, 2013 - ASBMB
The cytoplasmic lipid droplet (CLD) protein perilipin-2 (Plin2) is expressed in multiple
nonadipose tissues, where it is thought to play a role in regulating their lipid storage properties. …

[HTML][HTML] Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy

CI Bloom, CM Graham, MPR Berry, KA Wilkinson, T Oni… - 2012 - journals.plos.org
Rationale Globally there are approximately 9 million new active tuberculosis cases and 1.4
million deaths annually. Effective antituberculosis treatment monitoring is difficult as there are …

Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-D-glucose positron emission and computed tomography

…, RP Lai, M Lesosky, KA Wilkinson, CM Graham… - Nature medicine, 2016 - nature.com
Tuberculosis is classically divided into states of latent infection and active disease. Using
combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-…

[HTML][HTML] A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection

A Singhania, R Verma, CM Graham, J Lee… - Nature …, 2018 - nature.com
Whole blood transcriptional signatures distinguishing active tuberculosis patients from
asymptomatic latently infected individuals exist. Consensus has not been achieved regarding the …

School-aged children's vulnerability to depressive symptomatology: The role of attachment security, maternal depressive symptomatology, and economic risk

CA Graham, MA Easterbrooks - Development and Psychopathology, 2000 - cambridge.org
The influences of three risk factors (insecure attachment, maternal depressive symptoms,
and economic risk) on children's depressive symptomatology were examined. Subjects were …

Programmed death ligand 1 is over‐expressed by neutrophils in the blood of patients with active tuberculosis

FW McNab, MPR Berry, CM Graham… - European journal of …, 2011 - Wiley Online Library
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the world's
largest infectious disease problems. Despite decades of intensive study, the immune …

[HTML][HTML] Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza

…, S Blankley, LT Hoang, M Cox, CM Graham… - Nature …, 2018 - nature.com
Transcriptional profiles and host-response biomarkers are used increasingly to investigate
the severity, subtype and pathogenesis of disease. We now describe whole-blood mRNA …