[HTML][HTML] Analysis of the lung microbiome in the “healthy” smoker and in COPD

…, DL Thompson, MK Han, CM Freeman… - PloS one, 2011 - journals.plos.org
Although culture-independent techniques have shown that the lungs are not sterile, little is
known about the lung microbiome in chronic obstructive pulmonary disease (COPD). We …

Analysis of the upper respiratory tract microbiotas as the source of the lung and gastric microbiotas in healthy individuals

…, JR Erb-Downward, RP Dickson, CM Freeman… - MBio, 2015 - Am Soc Microbiol
No studies have examined the relationships between bacterial communities along sites of
the upper aerodigestive tract of an individual subject. Our objective was to perform an …

Spatial variation in the healthy human lung microbiome and the adapted island model of lung biogeography

…, JR Erb-Downward, CM Freeman… - Annals of the …, 2015 - atsjournals.org
Rationale: The lung microbiome is spatially heterogeneous in advanced airway diseases,
but whether it varies spatially in health is unknown. We postulated that the primary …

Bacterial topography of the healthy human lower respiratory tract

RP Dickson, JR Erb-Downward, CM Freeman… - MBio, 2017 - Am Soc Microbiol
Although culture-independent techniques have refuted lung sterility in health, controversy
about contamination during bronchoscope passage through the upper respiratory tract (URT) …

The immunopathogenesis of chronic obstructive pulmonary disease: insights from recent research

JL Curtis, CM Freeman, JC Hogg - Proceedings of the American …, 2007 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) progression is characterized by accumulation
of inflammatory mucous exudates in the lumens of small airways, and thickening of their …

Development of biodegradable electrospun scaffolds for dermal replacement

KA Blackwood, R McKean, I Canton, CO Freeman… - Biomaterials, 2008 - Elsevier
Our objective is to develop a synthetic biodegradable replacement dermal substitute for
tissue engineering of skin and oral mucosa. Our in vivo criteria were that candidate scaffolds …

Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort

…, RG Crystal, CM Doerschuk, CM Freeman… - The lancet respiratory …, 2017 - thelancet.com
Background Present treatment strategies to stratify exacerbation risk in patients with chronic
obstructive pulmonary disease (COPD) rely on a history of two or more events in the …

Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort

…, RG Crystal, MT Dransfield, CM Freeman… - The Lancet …, 2017 - thelancet.com
Background Increased concentrations of eosinophils in blood and sputum in chronic
obstructive pulmonary disease (COPD) have been associated with increased frequency of …

[HTML][HTML] At the root: defining and halting progression of early chronic obstructive pulmonary disease

…, RG Crystal, M Fagerås, CM Freeman… - American journal of …, 2018 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is a prevalent, heterogeneous disorder with
varying presentation and progression but with a limited number of disease-modifying …

Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling

…, JA Swanson, P Mancuso, CM Freeman… - Journal of Experimental …, 2015 - rupress.org
JAK-STAT signaling mediates the actions of numerous cytokines and growth factors, and its
endogenous brake is the family of SOCS proteins. Consistent with their intracellular roles, …