[HTML][HTML] Cemiplimab plus chemotherapy versus chemotherapy alone in non-small cell lung cancer: a randomized, controlled, double-blind phase 3 trial

…, M Nechaeva, I Rozhkova, E Kalinka, C Gessner… - Nature Medicine, 2022 - nature.com
First-line cemiplimab (anti-programmed cell death-1 (PD-1)) monotherapy has previously
shown significant improvement in overall survival (OS) and progression-free survival (PFS) …

Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): baseline data from a prospective cohort study

…, Q Zhang, P Badorrek, C Gessner… - The Lancet …, 2019 - thelancet.com
Background Small airways dysfunction (SAD) is well recognised in asthma, yet its role in the
severity and control of asthma is unclear. This study aimed to assess which combination of …

[HTML][HTML] Exhaled breath condensate cytokine patterns in chronic obstructive pulmonary disease

C Gessner, R Scheibe, M Wötzel, S Hammerschmidt… - Respiratory …, 2005 - Elsevier
Differences in cytokine patterns in stable chronic obstructive pulmonary disease (COPD),
exacerbated COPD, smokers without apparent COPD, and healthy volunteers should be of …

The role of small airway dysfunction in asthma control and exacerbations: a longitudinal, observational analysis using data from the ATLANTIS study

…, Q Zhang, P Badorrek, C Gessner… - The Lancet …, 2022 - thelancet.com
Background Although small airway disease is a feature of asthma, its association with
relevant asthma outcomes remains unclear. The ATLANTIS study was designed to identify the …

Long-term safety and efficacy of tezepelumab in people with severe, uncontrolled asthma (DESTINATION): a randomised, placebo-controlled extension study

A Menzies-Gow, ME Wechsler… - The Lancet …, 2023 - thelancet.com
Background Tezepelumab is a human monoclonal antibody that blocks thymic stromal
lymphopoietin. The drug has been tested previously in the phase 3 NAVIGATOR (NCT03347279) …

[HTML][HTML] Exhaled breath condensate acidification in acute lung injury

C Gessner, S Hammerschmidt, H Kuhn, HJ Seyfarth… - Respiratory …, 2003 - Elsevier
Lung injury in ventilated lungs may occur due to local or systemic disease and is usually
caused by or accompanied by inflammatory processes. Recently, acidification of exhaled breath …

Detection of p53 gene mutations in exhaled breath condensate of non-small cell lung cancer patients

C Gessner, H Kuhn, K Toepfer, S Hammerschmidt… - Lung cancer, 2004 - Elsevier
Early diagnosis of lung carcinoma is greatly desired. A potential source of early information
regarding the process of cancerisation in the airways is exhaled breath condensate (EBC). …

Apoptosis and necrosis induced by cyclic mechanical stretching in alveolar type II cells

…, H Kuhn, T Grasenack, C Gessner… - American journal of …, 2004 - atsjournals.org
Alveolar type II (ATII) cells are exposed to mechanical stretch during breathing and
mechanical ventilation. Increased stretch may contribute to lung injury. The influence of three …

[HTML][HTML] Fixed-dose combination of indacaterol/glycopyrronium/mometasone furoate once-daily versus salmeterol/fluticasone twice-daily plus tiotropium once-daily in …

C Gessner, O Kornmann, J Maspero, R van Zyl-Smit… - Respiratory …, 2020 - Elsevier
Background The efficacy and safety of once-daily (od) fixed-dose combination of indacaterol
(IND), glycopyrronium (GLY) and mometasone furoate (MF) via Breezhaler® versus …

Multiplex analysis of cytokines in exhaled breath condensate

…, G Hoheisel, H Wirtz, C Gessner - Cytometry Part A …, 2006 - Wiley Online Library
Background To improve monitoring of lung diseases, we analyzed cytokines in exhaled
breath condensate (EBC). The main challenge in measurement of cytokines in EBC is the low …