Introduction International guidelines recommend a severity-based approach to management
in community-acquired pneumonia. CURB65, CRB65 and the Pneumonia Severity Index (…

Background The aim of this meta-analysis was to determine if severity assessment tools can
be used to guide decisions regarding intensive care unit (ICU) admission of patients with …

Ageing is associated with a progressive degeneration of the tissues, which has a negative
impact on the structure and function of vital organs and is among the most important known …

Background. The recently introduced concept of health care–associated pneumonia (HCAP),
referring to patients with frequent healthcare contacts and at higher risk of contracting …

Background Alpha 1 -antitrypsin (AAT) deficiency results from carriage of a homozygous
SERPINA1 “Z” mutation (proteinase inhibitor [PI] ZZ). The Z allele produces a mutant AAT …

… Gourab Choudhury , Gourab Choudhury … Taylor, Pallavi Mandal, Gourab Choudhury, Aran
Singanayagam, Ahsan R. Akram, Adam T. Hill, Validation of the Infectious Diseases Society of …

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality
worldwide. It has been projected to move from the sixth to the third most common cause of …

Ageing is defined as a progressive decline of homeostasis that occurs after the reproductive
phase of life is complete, which is thought to arise because of impaired DNA repair following …

Introduction The multiorgan impact of moderate to severe coronavirus infections in the post-acute
phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan …

Background A consensus definition of acute kidney injury (AKI)—the risk, injury, failure, loss,
and end-stage kidney disease (RIFLE) classification—predicts mortality in general hospital …