The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130
European-descent individuals (9% cases), after imputation to high-density reference panels. …

Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …

Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states.
Previous genetic studies have largely focused on insulin resistance in the fasting state, …

White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral
small vessel disease (SVD), hypertension being the main known risk factor. Here, we …

OBJECTIVE Type 2 diabetes (T2D) has heterogeneous patient clinical characteristics and
outcomes. In previous work, we investigated the genetic basis of this heterogeneity by …

Clonal hematopoiesis of indeterminate potential (CHIP) is a premalignant expansion of
mutated hematopoietic stem cells. As CHIP-associated mutations are known to alter the …

Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

We assembled an ancestrally diverse collection of genome-wide association studies (GWAS)
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…

Macronutrient intake, the proportion of calories consumed from carbohydrate, fat, and
protein, is an important risk factor for metabolic diseases with significant familial aggregation. …