Two endothelin receptor antagonists (ERAs), bosentan and ambrisentan, are currently
approved for the treatment of pulmonary arterial hypertension (PAH), a devastating disease …

The competitive endothelin receptor antagonists (ERA) bosentan and ambrisentan, which
have long been approved for the treatment of pulmonary arterial hypertension, are …

Introduction The orexin neuropeptide–receptor system is a central sleep and wake regulator
in the brain. The two orexin receptor subtypes, OX1R and OX2R, are expressed either …

Association and dissociation rates of G protein-coupled receptor antagonists can influence
their in vivo pharmacological activity, such as duration of action, activity in situations of …

Methods Fifty participants (59.8±1.5 years; 31 women) completed 3 overnight in-hospital
stays. The first stay (S1) was a baseline control; the second stay (S2) followed a 4-week wait-list …

Methods We assessed CSA using portable polysomnography (ApneaLink, ResMed) during
ascent to 5160m in the Nepal Himalaya over 10 days in 15 healthy participants. Files were …

… We thank Célia Mueller Grandjean (Actelion Pharmaceuticals Ltd.) for technical assistance
with measurement of the bosentan analogues. SpiroChem is acknowledged for the generous …

… Chemistry team (Idorsia) for the synthesis of the compounds, Manon Kiry and Celia Mueller
Grandjean for measuring the Kbs in the Calcium mobilization and IP 1 accumulation assay. …

A series of dihydropyrazole derivatives was developed as potent, selective, and brain-penetrating
T-type calcium channel blockers. An optimized derivative, compound 6c, was …

The history of Central Brevard County is almost as long and complicated as the geographical
borders of the county itself. Stretching north and south for 77 miles, Brevard County is a …