User profiles for Cecilia Wikell
 | Cecilia WikellTeam Leader/Associate Principal Scientist, RIA iMed, AstraZeneca Verified email at astrazeneca.com Cited by 278 |
Discovery of second generation reversible covalent DPP1 inhibitors leading to an oxazepane amidoacetonitrile based clinical candidate (AZD7986)
A novel series of second generation DPP1 inhibitors free from aorta binding liabilities found
for earlier compound series was discovered. This work culminated in the identification of …
for earlier compound series was discovered. This work culminated in the identification of …
Altered open-field behavior in experimental chronic hepatic encephalopathy after single venlafaxine and citalopram challenges
G Apelqvist, C Wikell, B Hindfelt, PBF Bergqvist… - …, 1999 - Springer
Rationale: Latent or manifest chronic hepatic encephalopathy (HE) symptomatology often
includes affective symptoms. It is therefore warranted to investigate the functional outcome of …
includes affective symptoms. It is therefore warranted to investigate the functional outcome of …
Brain monoamine output alterations after a single venlafaxine challenge in experimental hepatic encephalopathy
Venlafaxine (VEN) phamacokinetics and effects on the brain monoaminc output were investigated
in the context of experimental hepatic encephalopathy (HE). Systemic VEN (10 mg/kg; …
in the context of experimental hepatic encephalopathy (HE). Systemic VEN (10 mg/kg; …
Sustained administration of the antidepressant venlafaxine in rats: pharmacokinetic and pharmacodynamic findings.
Rats were administered venlafaxine (10 mg/kg per day) for 14 days by using subcutaneously
implanted osmotic minipumps. The present study assessed the distribution of VEN in …
implanted osmotic minipumps. The present study assessed the distribution of VEN in …
Pharmacokinetic and pharmacodynamic responses to chronic administration of the selective serotonin reuptake inhibitor citalopram in rats
The number of drugs used to treat affective disorders such as depression is rapidly increasing.
Citalopram (CIT), an antideprcssant, is a selective serotonin (5-hydroxytryptamine; 5-HT) …
Citalopram (CIT), an antideprcssant, is a selective serotonin (5-hydroxytryptamine; 5-HT) …
[PDF][PDF] Quantitative studies of testicular atrophy following portacaval shunt in rats
AM Zaitoun, G Apelqvist, C Wikell, H Al‐mardini… - …, 1998 - Wiley Online Library
To evaluate the differential effects of portacaval shunting (PCS) on the morphological changes
that occur in humans with portal‐systemic encephalopathy, male rats underwent either …
that occur in humans with portal‐systemic encephalopathy, male rats underwent either …
Effects on drug disposition, brain monoamines and behavior after chronic treatment with the antidepressant venlafaxine in rats with experimental hepatic …
Patients with chronic hepatic encephalopathy (HE) may present affective symptoms and
antidepressant drug treatment in this condition is not uncommon. The present microdialysis …
antidepressant drug treatment in this condition is not uncommon. The present microdialysis …
Open‐Field Behavioural Alterations in Liver‐Impaired and Sham‐Operated Rats after Acute Exposure to the Antidepressant Venlafaxine
FC Kugelberg, G Apelqvist, C Wikell… - Basic & clinical …, 2005 - Wiley Online Library
Patients with chronic liver impairment often display symptoms of affective psychiatric nature
where the choice for antidepressant treatment is rational. Since caution is recommended …
where the choice for antidepressant treatment is rational. Since caution is recommended …
Effect of citalopram on brain serotonin release in experimental hepatic encephalopathy: implications for thymoleptic drug safety in liver insufficiency
In the present study, effects of citalopram (CIT) on brain 5-hydroxytryptamine (5-HT) release
in experimental chronic hepatic encephalopathy (HE) were investigated. Neocortical …
in experimental chronic hepatic encephalopathy (HE) were investigated. Neocortical …
Dynamic and kinetic effects of chronic citalopram treatment in experimental hepatic encephalopathy
Chronic hepatic encephalopathy (HE) is a neuropsychiatric syndrome that arises in liver-impaired
subjects. Patients with HE display various neuropsychiatric symptoms including …
subjects. Patients with HE display various neuropsychiatric symptoms including …