Diagnosis and the premotor phase of Parkinson disease

E Tolosa, C Gaig, J Santamaría, Y Compta - Neurology, 2009 - AAN Enterprises
Clinical, neuroimaging, and pathologic studies have provided data suggesting that a variety
of nonmotor symptoms can precede the classic motor features of Parkinson disease (PD) by …

When does Parkinson's disease begin?

C Gaig, E Tolosa - Movement Disorders, 2009 - Wiley Online Library
Pathological and neuroimaging studies have shown that in Parkinson's disease (PD) there
is a “subclinical” or “premotor” period during which dopaminergic neurons in the substantia …

Sleep-disordered breathing in neurodegenerative diseases

C Gaig, A Iranzo - Current neurology and neuroscience reports, 2012 - Springer
Sleep disorders are common in neurodegenerative diseases such as Parkinson’s disease (PD),
multiple system atrophy (MSA), amyotrophic lateral sclerosis (ALS), hereditary ataxias, …

Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study

…, F Lomeña, D Vilas, A LLadó, C Gaig… - The Lancet …, 2013 - thelancet.com
Background We postulated that idiopathic rapid-eye-movement (REM) sleep behaviour disorder
(IRBD) represents the prodromal phase of a Lewy body disorder and that, with sufficient …

Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study

…, P Cortelli, K Ehgoetz Martens, JF Gagnon, C Gaig… - Brain, 2019 - academic.oup.com
Idiopathic REM sleep behaviour disorder (iRBD) is a powerful early sign of Parkinson’s
disease, dementia with Lewy bodies, and multiple system atrophy. This provides an …

The O nset of N onmotor S ymptoms in P arkinson's disease (T he ONSET PD S tudy)

C Pont‐Sunyer, A Hotter, C Gaig, K Seppi… - Movement …, 2015 - Wiley Online Library
Nonmotor symptoms (NMS) in Parkinson's disease (PD) can precede onset of motor symptoms.
Relationship between premotor symptoms onset and motor features is limited. Our aim is …

[HTML][HTML] Neurodegenerative disorder risk in idiopathic REM sleep behavior disorder: study in 174 patients

…, E Gelpi, I Vilaseca, R Sánchez-Valle, A Lladó, C Gaig… - PloS one, 2014 - journals.plos.org
Objective To estimate the risk for developing a defined neurodegenerative syndrome in a
large cohort of idiopathic REM sleep behavior disorder (IRBD) patients with long follow-up. …

A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series …

L Sabater, C Gaig, E Gelpi, L Bataller… - The Lancet …, 2014 - thelancet.com
Background Autoimmunity might be associated with or implicated in sleep and neurodegenerative
disorders. We aimed to describe the features of a novel neurological syndrome …

Normative EMG values during REM sleep for the diagnosis of REM sleep behavior disorder

B Frauscher, A Iranzo, C Gaig, V Gschliesser, M Guaita… - Sleep, 2012 - academic.oup.com
Background: Correct diagnosis of rapid eye movement sleep behavior disorder (RBD) is
important because it can be the first manifestation of a neurodegenerative disease, it may lead …

Multiple organ involvement by alpha‐synuclein pathology in Lewy body disorders

E Gelpi, J Navarro‐Otano, E Tolosa, C Gaig… - Movement …, 2014 - Wiley Online Library
Lewy body (LB) diseases are characterized by alpha‐synuclein (AS) aggregates in the
central nervous system (CNS). Involvement of the peripheral autonomic nervous system (pANS) …