User profiles for Carla Winkler
Carla WinklerRIA iMed, AstraZeneca Verified email at astrazeneca.com Cited by 954 |
[HTML][HTML] Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD
C Winkler, EN Atochina-Vasserman, O Holz… - Respiratory …, 2011 - Springer
Background Pulmonary surfactant protein D (SP-D) is considered as a candidate biomarker
for the functional integrity of the lung and for disease progression, which can be detected in …
for the functional integrity of the lung and for disease progression, which can be detected in …
Expression of c‐Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells
Human type 2 innate lymphoid cells (ILC2) are the only ILC subset that shows heterogeneous
expression of the SCF receptor c‐Kit (CD117). Despite its use as surface marker to …
expression of the SCF receptor c‐Kit (CD117). Despite its use as surface marker to …
The neuropeptide calcitonin gene‐related peptide affects allergic airway inflammation by modulating dendritic cell function
…, C Pilzner, S Knothe, C Winkler… - Clinical & …, 2011 - Wiley Online Library
Background The neuropeptide calcitonin gene‐related peptide (CGRP) is released in the
lung by sensory nerves during allergic airway responses. Pulmonary dendritic cells (DC) …
lung by sensory nerves during allergic airway responses. Pulmonary dendritic cells (DC) …
Activation of group 2 innate lymphoid cells after allergen challenge in asthmatic patients
Background Group 2 innate lymphoid cells (ILC2s) are effective producers of IL-5 and IL-13
during allergic inflammation and bridge the innate and adaptive immune responses. ILC2 …
during allergic inflammation and bridge the innate and adaptive immune responses. ILC2 …
Pathogen reduction by ultraviolet C light effectively inactivates human white blood cells in platelet products
P Pohler, M Müller, C Winkler, D Schaudien… - …, 2015 - Wiley Online Library
Background Residual white blood cells ( WBC s) in cellular blood components induce a
variety of adverse immune events, including nonhemolytic febrile transfusion reactions, …
variety of adverse immune events, including nonhemolytic febrile transfusion reactions, …
Bronchoconstriction in nonhuman primates: a species comparison
…, E Fuchs, HD Lauenstein, C Winkler… - Journal of Applied …, 2011 - journals.physiology.org
Bronchoconstriction is a characteristic symptom of various chronic obstructive respiratory
diseases such as chronic obstructive pulmonary disease and asthma. Precision-cut lung slices (…
diseases such as chronic obstructive pulmonary disease and asthma. Precision-cut lung slices (…
[HTML][HTML] Low-dose endotoxin inhalation in healthy volunteers-a challenge model for early clinical drug development
…, O Holz, B Lavae-Mokhtari, L Welker, C Winkler… - BMC Pulmonary …, 2013 - Springer
Background Inhalation of endotoxin (LPS) induces a predominantly neutrophilic airway
inflammation and has been used as model to test the anti-inflammatory activity of novel drugs. In …
inflammation and has been used as model to test the anti-inflammatory activity of novel drugs. In …
Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma
Preclinical studies suggest that the endocannabinoid anandamide restrains allergic airway
obstruction and inflammation. Therefore, we applied saline or allergens via bronchoscopy …
obstruction and inflammation. Therefore, we applied saline or allergens via bronchoscopy …
Surfactant and allergic airway inflammation
C Winkler, JM Hohlfeld - Swiss medical weekly, 2013 - smw.ch
Pulmonary surfactant is a complex mixture of unique proteins and lipids that covers the airway
lumen. Surfactant prevents alveolar collapse and maintains airway patency by reducing …
lumen. Surfactant prevents alveolar collapse and maintains airway patency by reducing …
[HTML][HTML] Effects of ultrafine particles on the allergic inflammation in the lung of asthmatics: results of a double-blinded randomized cross-over clinical pilot study
…, H Windt, E Karg, M Müller, C Winkler… - Particle and fibre …, 2014 - Springer
Background Epidemiological and experimental studies suggest that exposure to ultrafine
particles (UFP) might aggravate the allergic inflammation of the lung in asthmatics. Methods …
particles (UFP) might aggravate the allergic inflammation of the lung in asthmatics. Methods …