User profiles for Carla Winkler

Carla Winkler

RIA iMed, AstraZeneca
Verified email at astrazeneca.com
Cited by 954

[HTML][HTML] Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD

C Winkler, EN Atochina-Vasserman, O Holz… - Respiratory …, 2011 - Springer
Background Pulmonary surfactant protein D (SP-D) is considered as a candidate biomarker
for the functional integrity of the lung and for disease progression, which can be detected in …

Expression of c‐Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells

T Hochdörfer, C Winkler, K Pardali… - European journal of …, 2019 - Wiley Online Library
Human type 2 innate lymphoid cells (ILC2) are the only ILC subset that shows heterogeneous
expression of the SCF receptor c‐Kit (CD117). Despite its use as surface marker to …

The neuropeptide calcitonin gene‐related peptide affects allergic airway inflammation by modulating dendritic cell function

…, C Pilzner, S Knothe, C Winkler… - Clinical & …, 2011 - Wiley Online Library
Background The neuropeptide calcitonin gene‐related peptide (CGRP) is released in the
lung by sensory nerves during allergic airway responses. Pulmonary dendritic cells (DC) …

Activation of group 2 innate lymphoid cells after allergen challenge in asthmatic patients

C Winkler, T Hochdörfer, E Israelsson… - Journal of Allergy and …, 2019 - Elsevier
Background Group 2 innate lymphoid cells (ILC2s) are effective producers of IL-5 and IL-13
during allergic inflammation and bridge the innate and adaptive immune responses. ILC2 …

Pathogen reduction by ultraviolet C light effectively inactivates human white blood cells in platelet products

P Pohler, M Müller, C Winkler, D Schaudien… - …, 2015 - Wiley Online Library
Background Residual white blood cells ( WBC s) in cellular blood components induce a
variety of adverse immune events, including nonhemolytic febrile transfusion reactions, …

Bronchoconstriction in nonhuman primates: a species comparison

…, E Fuchs, HD Lauenstein, C Winkler… - Journal of Applied …, 2011 - journals.physiology.org
Bronchoconstriction is a characteristic symptom of various chronic obstructive respiratory
diseases such as chronic obstructive pulmonary disease and asthma. Precision-cut lung slices (…

[HTML][HTML] Low-dose endotoxin inhalation in healthy volunteers-a challenge model for early clinical drug development

…, O Holz, B Lavae-Mokhtari, L Welker, C Winkler… - BMC Pulmonary …, 2013 - Springer
Background Inhalation of endotoxin (LPS) induces a predominantly neutrophilic airway
inflammation and has been used as model to test the anti-inflammatory activity of novel drugs. In …

Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma

…, S Engeli, S Batkai, C Winkler… - Clinical …, 2011 - Wiley Online Library
Preclinical studies suggest that the endocannabinoid anandamide restrains allergic airway
obstruction and inflammation. Therefore, we applied saline or allergens via bronchoscopy …

Surfactant and allergic airway inflammation

C Winkler, JM Hohlfeld - Swiss medical weekly, 2013 - smw.ch
Pulmonary surfactant is a complex mixture of unique proteins and lipids that covers the airway
lumen. Surfactant prevents alveolar collapse and maintains airway patency by reducing …

[HTML][HTML] Effects of ultrafine particles on the allergic inflammation in the lung of asthmatics: results of a double-blinded randomized cross-over clinical pilot study

…, H Windt, E Karg, M Müller, C Winkler… - Particle and fibre …, 2014 - Springer
Background Epidemiological and experimental studies suggest that exposure to ultrafine
particles (UFP) might aggravate the allergic inflammation of the lung in asthmatics. Methods …