Background Bortezomib with dexamethasone is a standard treatment option for relapsed or
refractory multiple myeloma. Carfilzomib with dexamethasone has shown promising activity …

Polycomb proteins maintain cell identity by repressing the expression of developmental
regulators specific for other cell types. Polycomb repressive complex-2 (PRC2) catalyzes …

The Intergroupe Francophone du Myelome conducted a randomized trial to compare
bortezomib-dexamethasone (VD) as induction before high-dose therapy (HDT) and autologous …

Background As lenalidomide becomes increasingly established for upfront treatment of
multiple myeloma, patients refractory to this drug represent a population with an unmet need. …

The Intergroupe Francophone du Myélome conducted a randomized trial to compare
bortezomib-thalidomide-dexamethasone (VTD) with bortezomib-cyclophosphamide-…

Autologous stem cell transplantation (ASCT) is recommended for younger patients with
newly diagnosed multiple myeloma. Achieving complete response (CR) or at least very good …

Vitrinite reflectance generally is considered the most robust thermal maturity parameter
available for application to hydrocarbon exploration and petroleum system evaluation. However, …

Guidelines for monitoring multiple myeloma (MM) patients expressing light chains only (light-chain
MM [LCMM]) rely on measurements of monoclonal protein in urine. Alternatively, …

The Pera-Lakkos coal located on top of bauxite deposits in the Ghiona mining district (Central
Greece), is the only known Mesozoic (Late Cretaceous) coal in the country. It was derived …

Objectives Prompt diagnosis of acute coronary syndrome (ACS) remains a challenge, with
presenting symptoms affecting the diagnosis algorithm and, consequently, management and …