… Here, we show that among 30 members of the human mycobiome, C. albicans is the major
inducer of Th17 cells in humans. C. albicans-specific T cell responses broadly modulate …

Macrophages can be niches for bacterial pathogens or antibacterial effector cells depending
on the pathogen and signals from the immune system. Here we show that type I and II IFNs …

… 37C sterile saline for 5 min. Lungs were homogenized at 4C. Serial dilutions of lung samples
were plated on blood agar and incubated at 37C for 16 h before colonies were counted. …

… For imaging of endothelial cytosolic Ca 2+ concentration ([Ca 2+ ] i ), lungs were positioned
under an upright fluorescence microscope and superfused with normal saline at 37C. Fura-2-…

… Loaded neutrophils were washed with 37C warm PBS, and 1 × 10 5 neutrophils were … 2
and 37C, cells were washed with PBS and fixed in 2% paraformaldehyde for 30 minutes at 4C, …

… in Cx40 +/+ lungs perfused with the nonspecific gap junction inhibitor 18α-glycyrrhetinic
acid (50 μM) or the Cx40-specific inhibitory mimetic peptide gap27 40 (200 μM; Figure 2C). …

… Mice were backcrossed 10 generations on a C56BL/6 and Balb/c background. Knockout …
DO11.10 ovalbumin (OVA) peptide-specific T-cell receptor (TCR) transgenic mice (BALB/c …

Hypoxic pulmonary vasoconstriction (HPV) optimizes pulmonary ventilation-perfusion matching
in regional hypoxia, but promotes pulmonary hypertension in global hypoxia. Ventilation-…

Defence mechanisms against intracellular bacterial pathogens are incompletely understood.
Our study characterizes a type I IFN‐dependent cell‐autonomous defence pathway …

Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). Type I interferons are important in the defense of …