Major advances in our understanding of the universe have historically arisen from dramatic
improvements in our ability to “see.” We have developed progressively larger telescopes …

… lead times for heatwave Event C. Ensemble boosting yields … exceedance of the respective
Event C is largest. For longer … intensity of corresponding Event C by an additional 2.5 C (Fig. 2b…

… 2 O which scales the N 2 O lifetime with the factor C N 2 O t C N 2 O 0 S τ N 2 O , where C N
2 O t is the current atmospheric burden at time t and C N 2 O 0 the pre-industrial burden ( S τ …

… c, ORR in correlation with baseline PD-L1 levels. ORR and the corresponding two-sided
95% CI were calculated using the Clopper–Pearson method. d, Tumor response in correlation …

Background Small airways dysfunction (SAD) is well recognised in asthma, yet its role in the
severity and control of asthma is unclear. This study aimed to assess which combination of …

Background Tezepelumab is a human monoclonal antibody that blocks thymic stromal
lymphopoietin. The drug has been tested previously in the phase 3 NAVIGATOR (NCT03347279) …

The availability of energy appears to exert important regulatory functions in pituitary-adrenal
stress responses. In two studies, the effects of short-term fasting and subsequent glucose …

We describe here the most ambitious survey currently planned in the optical, the Large
Synoptic Survey Telescope (LSST). The LSST design is driven by four main science themes: …

Background Although small airway disease is a feature of asthma, its association with
relevant asthma outcomes remains unclear. The ATLANTIS study was designed to identify the …

Differences in cytokine patterns in stable chronic obstructive pulmonary disease (COPD),
exacerbated COPD, smokers without apparent COPD, and healthy volunteers should be of …