Global Initiative for Asthma Strategy 2021: executive summary and rationale for key changes

…, LB Bacharier, ED Bateman, CE Brightling… - American journal of …, 2022 - atsjournals.org
The Global Initiative for Asthma (GINA) Strategy Report provides clinicians with an annually
updated evidence-based strategy for asthma management and prevention, which can be …

Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs

…, AL Boner, J Bouchard, F Braido, CE Brightling… - Journal of Allergy and …, 2012 - Elsevier
Allergic rhinitis (AR) and asthma represent global health problems for all age groups.
Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on …

Targeting TNF-α: a novel therapeutic approach for asthma

C Brightling, M Berry, Y Amrani - Journal of Allergy and Clinical …, 2008 - Elsevier
… AHR could be caused by a direct effect of TNF-α on airway smooth muscle (ASM), as
outlined in detail below, or indirectly by the release of the cysteinyl leukotrienes C 4 and D 4 . In …

Effect of dexamethasone in hospitalized patients with COVID-19–preliminary report

…, M Mafham, J Bell, L Linsell, N Staplin, C Brightling… - MedRxiv, 2020 - medrxiv.org
Background Coronavirus disease 2019 (COVID-19) is associated with diffuse lung damage.
Corticosteroids may modulate immune-mediated lung injury and reducing progression to …

[HTML][HTML] Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study

…, K Poinasamy, LV Wain, CE Brightling… - The Lancet …, 2021 - thelancet.com
Background The impact of COVID-19 on physical and mental health and employment after
hospitalisation with acute disease is not well understood. The aim of this study was to …

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

…, ER Bleecker, LP Boulet, C Brightling… - European respiratory …, 2014 - Eur Respiratory Soc
Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A
Task Force, supported by the European Respiratory Society and American Thoracic Society, …

Cluster analysis and clinical asthma phenotypes

…, MA Berry, M Thomas, CE Brightling… - American journal of …, 2008 - atsjournals.org
Rationale: Heterogeneity in asthma expression is multidimensional, including variability in
clinical, physiologic, and pathologic parameters. Classification requires consideration of …

Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial

RH Green, CE Brightling, S McKenna, B Hargadon… - The Lancet, 2002 - thelancet.com
C Brightling designed the protocol and obtained funding for the study, did the randomisation
and revised the report. S McKenna and B Hargadon assisted with study recruitment, did the …

[HTML][HTML] Mepolizumab and exacerbations of refractory eosinophilic asthma

P Haldar, CE Brightling, B Hargadon… - New England journal …, 2009 - Mass Medical Soc
Background Exacerbations of asthma are associated with substantial morbidity and mortality
and with considerable use of health care resources. Preventing exacerbations remains an …

[HTML][HTML] Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge

…, SK Piechnik, P Klenerman, C Brightling… - …, 2021 - thelancet.com
… I: Relationship between basal native T 1 and C-reactive protein (CRP). J, K: Comparison of
liver T 1 and iron-corrected liver T 1 between control and COVID-19 survivors (these values …