This chapter provides methods suitable for the culture of primary human keratinocytes in
serum-free culture conditions, starting from very small skin biopsies. It also explains procedures …

Background The variability in the inflammatory burden of the lung in cystic fibrosis (CF)
patients together with the variable effect of glucocorticoid treatment led us to hypothesize that …

0923-1811/$36.00© 2013 Japanese Society for Investigative Dermatology. Published by
Elsevier Ireland Ltd. All rights reserved. expression restricted to the basal layer [9]. In contrast, …

Defective CFTR function in the airway epithelium is responsible for cystic fibrosis (CF)
patient lung disease. CFTR represents the most important pathway for apical chloride (Cl-) …

ABCA3 (ATP-binding cassette subfamily A, member 3) is expressed in the lamellar bodies
of alveolar type II cells and is crucial to pulmonary surfactant storage and homeostasis. …

Transcription nuclear factor-κB (NF-κB) is hyperactivated in cystic fibrosis (CF) lung epithelial
cells, and participates in exaggerated IL-8 production in the CF lung. We recently found …

The clinical course of cystic fibrosis (CF) varies between patients bearing identical CFTR
mutations, suggesting the involvement of modifier genes. We assessed the association of lung …

The clinical course of cystic fibrosis (CF) varies considerably among patients carrying the
same CF‐causing gene mutation. Additional genetic modifiers may contribute to this variability. …

BACKGROUND: The clinical course of cystic fibrosis (CF) lung disease varies between
patients bearing identical CFTR mutations. This suggests that additional genetic modifiers may …

L’inflammation précoce et excessive des voies respiratoires joue un rôle prépondérant
dans la progression de l’atteinte pulmonaire dans la mucoviscidose. Cette inflammation est …