Tiotropium, a long-acting anticholinergic, is delivered via HandiHaler or via Respimat.
Randomised controlled trials suggest that use of tiotropium Respimat increases the risk of dying. …

… de Keyser, and Bruno C. Stricker collected data on cancer incidence. Jessica C. Kiefte-de
Jong had primary responsibility for the final content. All authors read and approved the final …

General practice research databases are increasingly used to study intended and unintended
effects of treatments. However, confounding by indication remains a major problem. The …

Objectives CYP3A4 is involved in the oxidative metabolism of many drugs and xenobiotics
including the HMG-CoA reductase inhibitor simvastatin. The objective of this study was to …

Benzodiazepines and benzodiazepine-related medications (BBRMs) are anxiolytics and
hypnotics acting on γ-amino butyric acid (GABA) A receptors. BBRMs are assumed to have a …

Background: COPD is an independent risk factor for the presence of carotid artery wall
thickening and vulnerable lipid core plaques. Aims: To investigate whether the risk of carotid wall …

Objectives: In order to assess whether chest pain attributed to sumatriptan is associated
with abnormalities on cardiac exercise testing, we performed a case-control study. Subjects: …

Objectives : This study sought to investigate whether prolongation of the heart rate-corrected
QT (QTc) interval is a risk factor for sudden cardiac death in the general population. …

Aims To determine the prevalence, incidence rate, lifetime risk and prognosis of heart failure.
Methods and Results The Rotterdam Study is a prospective population-based cohort study …

ContextReduction of gastric acid secretion by acid-suppressive therapy allows pathogen
colonization from the upper gastrointestinal tract. The bacteria and viruses in the contaminated …