Lipid mediator class switching during acute inflammation: signals in resolution
Leukotrienes (LTs) and prostaglandins (PGs) amplify acute inflammation, whereas lipoxins (LXs)
have unique anti-inflammatory actions. Temporal analyses of these eicosanoids in …
have unique anti-inflammatory actions. Temporal analyses of these eicosanoids in …
COVID-19–related genes in sputum cells in asthma. Relationship to demographic features and corticosteroids
Rationale: Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). ACE2 (angiotensin-converting enzyme 2), and TMPRSS2 (…
coronavirus 2 (SARS-CoV-2). ACE2 (angiotensin-converting enzyme 2), and TMPRSS2 (…
[HTML][HTML] Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators
CN Serhan, BD Levy - The Journal of clinical investigation, 2018 - Am Soc Clin Investig
Countless times each day, the acute inflammatory response protects us from invading microbes,
injuries, and insults from within, as in surgery-induced tissue injury. These challenges …
injuries, and insults from within, as in surgery-induced tissue injury. These challenges …
Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma
…, S Kazani, ME Wechsler, E Israel, BD Levy - Science translational …, 2013 - science.org
Asthma is a prevalent disease of chronic inflammation in which endogenous counterregulatory
signaling pathways are dysregulated. Recent evidence suggests that innate lymphoid …
signaling pathways are dysregulated. Recent evidence suggests that innate lymphoid …
Resolvin E1 regulates interleukin 23, interferon-γ and lipoxin A4 to promote the resolution of allergic airway inflammation
…, M Cernadas, R Yang, CN Serhan, BD Levy - Nature …, 2008 - nature.com
Interleukin 23 (IL-23) is integral to the pathogenesis of chronic inflammation. The resolution
of acute inflammation is an active process mediated by specific signals and mediators such …
of acute inflammation is an active process mediated by specific signals and mediators such …
Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4
BD Levy, GT De Sanctis, PR Devchand, E Kim… - Nature medicine, 2002 - nature.com
The prevalence of asthma continues to increase and its optimal treatment remains a challenge.
Here, we investigated the actions of lipoxin A 4 (LXA 4 ) and its leukocyte receptor in …
Here, we investigated the actions of lipoxin A 4 (LXA 4 ) and its leukocyte receptor in …
Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report
… BD Levy holds, or is listed as an inventor on, US patent applications #20080064746 entitled
“Lipoxins and aspirin-triggered lipoxins and their stable analogs in the treatment of asthma …
“Lipoxins and aspirin-triggered lipoxins and their stable analogs in the treatment of asthma …
Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness
BD Levy, P Kohli, K Gotlinger, O Haworth… - The Journal of …, 2007 - journals.aai.org
Protectins are newly identified natural chemical mediators that counter leukocyte activation
to promote resolution of inflammation. In this study, we provide the first evidence for protectin …
to promote resolution of inflammation. In this study, we provide the first evidence for protectin …
Inherited causes of clonal haematopoiesis in 97,691 whole genomes
Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …
Characterization of the severe asthma phenotype by the national heart, lung, and blood institute's severe asthma research program
…, I Hussain, NN Jarjour, E Israel, BD Levy… - Journal of Allergy and …, 2007 - Elsevier
BACKGROUND: Severe asthma causes the majority of asthma morbidity. Understanding
mechanisms that contribute to the development of severe disease is important. OBJECTIVE: …
mechanisms that contribute to the development of severe disease is important. OBJECTIVE: …