Lipid mediator class switching during acute inflammation: signals in resolution

BD Levy, CB Clish, B Schmidt, K Gronert… - Nature …, 2001 - nature.com
Leukotrienes (LTs) and prostaglandins (PGs) amplify acute inflammation, whereas lipoxins (LXs)
have unique anti-inflammatory actions. Temporal analyses of these eicosanoids in …

COVID-19–related genes in sputum cells in asthma. Relationship to demographic features and corticosteroids

…, SE Wenzel, E Israel, BD Levy… - American journal of …, 2020 - atsjournals.org
Rationale: Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). ACE2 (angiotensin-converting enzyme 2), and TMPRSS2 (…

[HTML][HTML] Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

CN Serhan, BD Levy - The Journal of clinical investigation, 2018 - Am Soc Clin Investig
Countless times each day, the acute inflammatory response protects us from invading microbes,
injuries, and insults from within, as in surgery-induced tissue injury. These challenges …

Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma

…, S Kazani, ME Wechsler, E Israel, BD Levy - Science translational …, 2013 - science.org
Asthma is a prevalent disease of chronic inflammation in which endogenous counterregulatory
signaling pathways are dysregulated. Recent evidence suggests that innate lymphoid …

Resolvin E1 regulates interleukin 23, interferon-γ and lipoxin A4 to promote the resolution of allergic airway inflammation

…, M Cernadas, R Yang, CN Serhan, BD Levy - Nature …, 2008 - nature.com
Interleukin 23 (IL-23) is integral to the pathogenesis of chronic inflammation. The resolution
of acute inflammation is an active process mediated by specific signals and mediators such …

Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4

BD Levy, GT De Sanctis, PR Devchand, E Kim… - Nature medicine, 2002 - nature.com
The prevalence of asthma continues to increase and its optimal treatment remains a challenge.
Here, we investigated the actions of lipoxin A 4 (LXA 4 ) and its leukocyte receptor in …

Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report

…, JM Hanifin, C Jones, M Kraft, BD Levy… - Journal of Pediatric …, 2011 - Elsevier
… BD Levy holds, or is listed as an inventor on, US patent applications #20080064746 entitled
“Lipoxins and aspirin-triggered lipoxins and their stable analogs in the treatment of asthma …

Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness

BD Levy, P Kohli, K Gotlinger, O Haworth… - The Journal of …, 2007 - journals.aai.org
Protectins are newly identified natural chemical mediators that counter leukocyte activation
to promote resolution of inflammation. In this study, we provide the first evidence for protectin …

Inherited causes of clonal haematopoiesis in 97,691 whole genomes

…, Y Liu, L Hou, J Lee, P Kachroo, BI Freedman, D Levy… - Nature, 2020 - nature.com
Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …

Characterization of the severe asthma phenotype by the national heart, lung, and blood institute's severe asthma research program

…, I Hussain, NN Jarjour, E Israel, BD Levy… - Journal of Allergy and …, 2007 - Elsevier
BACKGROUND: Severe asthma causes the majority of asthma morbidity. Understanding
mechanisms that contribute to the development of severe disease is important. OBJECTIVE: …