User profiles for Bruce C. Trapnell

Bruce C. Trapnell, MD

Professor of Medicine and Pediatrics, University of Cincinnati
Verified email at cchmc.org
Cited by 25108

In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

MA Rosenfeld, K Yoshimura, BC Trapnell, K Yoneyama… - Cell, 1992 - cell.com
Direct transfer of the normal cystic fibrosis (CF) transmembrane conductance regulator (CFTR)
gene to airway epitheiium was evaluated using a replicationdeficient recombinant …

[HTML][HTML] Efficacy and safety of sirolimus in lymphangioleiomyomatosis

…, HS Lee, JP Krischer, BC Trapnell - … England Journal of …, 2011 - Mass Medical Soc
Background Lymphangioleiomyomatosis (LAM) is a progressive, cystic lung disease in
women; it is associated with inappropriate activation of mammalian target of rapamycin (mTOR) …

Pulmonary alveolar proteinosis

BC Trapnell, JA Whitsett, K Nakata - New England Journal of …, 2003 - Mass Medical Soc
In acquired pulmonary alveolar proteinosis, lipids and proteins accumulate within the
alveoli because alveolar macrophages cannot catabolize surfactants. Surprisingly, alveolar …

Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy

N Mittereder, KL March, BC Trapnell - Journal of virology, 1996 - Am Soc Microbiol
Development of adenovirus vectors as potential therapeutic agents for multiple applications
of in vivo human gene therapy has resulted in numerous preclinical and clinical studies. …

[PDF][PDF] GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU. 1

…, ZC Chroneos, M Yoshida, JA Whitsett, BC Trapnell - Immunity, 2001 - cell.com
GM-CSF gene targeted (GM −/− ) mice are susceptible to respiratory infections and develop
alveolar proteinosis due to defects in innate immune function and surfactant catabolism in …

Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study

…, BS Kirschner, AS Patel, D Ziring, BC Trapnell… - The Lancet, 2017 - thelancet.com
Background Stricturing and penetrating complications account for substantial morbidity and
health-care costs in paediatric and adult onset Crohn's disease. Validated models to predict …

Genetic basis of variable exon 9 skipping in cystic fibrosis transmembrane conductance regulator mRNA

CS Chu, BC Trapnell, S Curristin, GR Cutting… - Nature …, 1993 - nature.com
Variable in–frame skipping of exon 9 in cystic fibrosis transmembrane conductance regulator
(CFTR) mRNA transcripts (exon 9 − ) occurs in the respiratory epithelium. To explore the …

Diffuse lung disease in young children: application of a novel classification scheme

…, LM Nogee, BC Trapnell, C Langston… - American journal of …, 2007 - atsjournals.org
Rationale: Considerable confusion exists regarding nomenclature, classification, and
management of pediatric diffuse lung diseases due to the relative rarity and differences in the …

Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan

Y Inoue, BC Trapnell, R Tazawa, T Arai… - American journal of …, 2008 - atsjournals.org
Rationale: Acquired pulmonary alveolar proteinosis (PAP) is a syndrome characterized by
pulmonary surfactant accumulation occurring in association with granulocyte/macrophage …

Gm-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense

BC Trapnell, JA Whitsett - Annual review of physiology, 2002 - annualreviews.org
▪ Abstract Recent studies in transgenic mice have revealed important insights into the roles
of GM-CSF in regulation of surfactant homeostasis and lung host defense. Interruption of the …