User profiles for Bruce C. Trapnell
Bruce C. Trapnell, MDProfessor of Medicine and Pediatrics, University of Cincinnati Verified email at cchmc.org Cited by 25108 |
In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium
MA Rosenfeld, K Yoshimura, BC Trapnell, K Yoneyama… - Cell, 1992 - cell.com
Direct transfer of the normal cystic fibrosis (CF) transmembrane conductance regulator (CFTR)
gene to airway epitheiium was evaluated using a replicationdeficient recombinant …
gene to airway epitheiium was evaluated using a replicationdeficient recombinant …
[HTML][HTML] Efficacy and safety of sirolimus in lymphangioleiomyomatosis
…, HS Lee, JP Krischer, BC Trapnell - … England Journal of …, 2011 - Mass Medical Soc
Background Lymphangioleiomyomatosis (LAM) is a progressive, cystic lung disease in
women; it is associated with inappropriate activation of mammalian target of rapamycin (mTOR) …
women; it is associated with inappropriate activation of mammalian target of rapamycin (mTOR) …
Pulmonary alveolar proteinosis
BC Trapnell, JA Whitsett, K Nakata - New England Journal of …, 2003 - Mass Medical Soc
In acquired pulmonary alveolar proteinosis, lipids and proteins accumulate within the
alveoli because alveolar macrophages cannot catabolize surfactants. Surprisingly, alveolar …
alveoli because alveolar macrophages cannot catabolize surfactants. Surprisingly, alveolar …
Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy
N Mittereder, KL March, BC Trapnell - Journal of virology, 1996 - Am Soc Microbiol
Development of adenovirus vectors as potential therapeutic agents for multiple applications
of in vivo human gene therapy has resulted in numerous preclinical and clinical studies. …
of in vivo human gene therapy has resulted in numerous preclinical and clinical studies. …
[PDF][PDF] GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU. 1
…, ZC Chroneos, M Yoshida, JA Whitsett, BC Trapnell - Immunity, 2001 - cell.com
GM-CSF gene targeted (GM −/− ) mice are susceptible to respiratory infections and develop
alveolar proteinosis due to defects in innate immune function and surfactant catabolism in …
alveolar proteinosis due to defects in innate immune function and surfactant catabolism in …
Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study
…, BS Kirschner, AS Patel, D Ziring, BC Trapnell… - The Lancet, 2017 - thelancet.com
Background Stricturing and penetrating complications account for substantial morbidity and
health-care costs in paediatric and adult onset Crohn's disease. Validated models to predict …
health-care costs in paediatric and adult onset Crohn's disease. Validated models to predict …
Genetic basis of variable exon 9 skipping in cystic fibrosis transmembrane conductance regulator mRNA
CS Chu, BC Trapnell, S Curristin, GR Cutting… - Nature …, 1993 - nature.com
Variable in–frame skipping of exon 9 in cystic fibrosis transmembrane conductance regulator
(CFTR) mRNA transcripts (exon 9 − ) occurs in the respiratory epithelium. To explore the …
(CFTR) mRNA transcripts (exon 9 − ) occurs in the respiratory epithelium. To explore the …
Diffuse lung disease in young children: application of a novel classification scheme
…, LM Nogee, BC Trapnell, C Langston… - American journal of …, 2007 - atsjournals.org
Rationale: Considerable confusion exists regarding nomenclature, classification, and
management of pediatric diffuse lung diseases due to the relative rarity and differences in the …
management of pediatric diffuse lung diseases due to the relative rarity and differences in the …
Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan
Y Inoue, BC Trapnell, R Tazawa, T Arai… - American journal of …, 2008 - atsjournals.org
Rationale: Acquired pulmonary alveolar proteinosis (PAP) is a syndrome characterized by
pulmonary surfactant accumulation occurring in association with granulocyte/macrophage …
pulmonary surfactant accumulation occurring in association with granulocyte/macrophage …
Gm-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense
BC Trapnell, JA Whitsett - Annual review of physiology, 2002 - annualreviews.org
▪ Abstract Recent studies in transgenic mice have revealed important insights into the roles
of GM-CSF in regulation of surfactant homeostasis and lung host defense. Interruption of the …
of GM-CSF in regulation of surfactant homeostasis and lung host defense. Interruption of the …