Although physical activity and sedentary behavior are moderately heritable, little is known
about the mechanisms that influence these traits. Combining data for up to 703,901 …

Background We aimed to identify novel genetic variants affecting asthma risk, since these
might provide novel insights into molecular mechanisms underlying the disease. Methods We …

Background To date, no genome-wide association study (GWAS) has considered the
combined phenotype of asthma with hay fever. Previous analyses of family data from the …

Eczema often precedes the development of asthma in a disease course called the ‘atopic
march’. To unravel the genes underlying this characteristic pattern of allergic disease, we …

Objective: To determine trends in incidence of malignant mesothelioma (MM) caused by
exposure to asbestos during home maintenance and renovation. Design, setting and …

Asthma, atopy, and related phenotypes are heterogeneous complex traits, with both genetic
and environmental risk factors. Extensive research has been conducted and over hundred …

Prostate cancer risk was examined in relation to intakes of fruit, vegetables, β-carotene and
retinol. Subjects were a cohort of 1985 men previously to asbestos who participated in a …

Background Genome-wide association studies (GWAS) have identified numerous loci
influencing cross-sectional lung function, but less is known about genes influencing longitudinal …

The impact of crocidolite exposure on the health of former Wittenoom miners and millers (largely
male) has been well documented. Less is known about the health outcomes of the …

Background and objective Chronic medical conditions accumulate within individuals with
age. However, knowledge concerning the trends, patterns and determinants of multimorbidity …