[HTML][HTML] Granuloma formation in pulmonary sarcoidosis
…, RW Hendriks, M Kool, B van den Blink - Frontiers in …, 2013 - frontiersin.org
Sarcoidosis is a granulomatous disorder of unknown cause, affecting multiple organs, but
mainly the lungs. The exact order of immunological events remains obscure. Reviewing …
mainly the lungs. The exact order of immunological events remains obscure. Reviewing …
[HTML][HTML] Mode of dendritic cell activation: the decisive hand in Th2/Th17 cell differentiation. Implications in asthma severity?
H Vroman, B van den Blink, M Kool - Immunobiology, 2015 - Elsevier
Asthma is a heterogeneous chronic inflammatory disease of the airways, with reversible
airflow limitations and airway remodeling. The classification of asthma phenotypes was initially …
airflow limitations and airway remodeling. The classification of asthma phenotypes was initially …
Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease
D Hommes, B Van Den Blink, T Plasse, J Bartelsman… - Gastroenterology, 2002 - Elsevier
BACKGROUND & AIMS:: We investigated if inhibition of mitogen-activated protein kinases (MAPKs)
was beneficial in Crohn's disease. METHODS:: Inhibition of JNK and p38 MAPK …
was beneficial in Crohn's disease. METHODS:: Inhibition of JNK and p38 MAPK …
Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia
J Branger, B van den Blink, S Weijer… - The journal of …, 2002 - journals.aai.org
The p38 mitogen-activated protein kinase (MAPK) participates in intracellular signaling
cascades resulting in inflammatory responses. Therefore, inhibition of the p38 MAPK pathway …
cascades resulting in inflammatory responses. Therefore, inhibition of the p38 MAPK pathway …
Endosonography vs conventional bronchoscopy for the diagnosis of sarcoidosis: the GRANULOMA randomized clinical trial
…, KG Tournoy, M Claussen, B van den Blink… - Jama, 2013 - jamanetwork.com
Importance Tissue verification of noncaseating granulomas is recommended for the diagnosis
of sarcoidosis. Bronchoscopy with transbronchial lung biopsies, the current diagnostic …
of sarcoidosis. Bronchoscopy with transbronchial lung biopsies, the current diagnostic …
IFN-γ–producing T-helper 17.1 cells are increased in sarcoidosis and are more prevalent than T-helper type 1 cells
…, BS Benn, RW Hendriks, B van den Blink… - American journal of …, 2016 - atsjournals.org
Rationale: Pulmonary sarcoidosis is classically defined by T-helper (Th) cell type 1 inflammation
(eg, IFN-γ production by CD4 + effector T cells). Recently, IL-17A–secreting cells have …
(eg, IFN-γ production by CD4 + effector T cells). Recently, IL-17A–secreting cells have …
Effect of recombinant human pentraxin 2 vs placebo on change in forced vital capacity in patients with idiopathic pulmonary fibrosis: a randomized clinical trial
G Raghu, B Van Den Blink, MJ Hamblin, AW Brown… - Jama, 2018 - jamanetwork.com
Importance Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with
poor prognosis. Approved therapies do not halt disease progression. Objective To determine …
poor prognosis. Approved therapies do not halt disease progression. Objective To determine …
Increased IL-17A expression in granulomas and in circulating memory T cells in sarcoidosis
…, MS Paats, IM Bergen, B van den Blink… - …, 2012 - academic.oup.com
Objective. Sarcoidosis is a systemic inflammatory disorder characterized by granulomas.
Although the aetiology is unknown, sarcoidosis is thought to be mediated by Th1 lymphocytes. …
Although the aetiology is unknown, sarcoidosis is thought to be mediated by Th1 lymphocytes. …
Ziritaxestat, a novel autotaxin inhibitor, and lung function in idiopathic pulmonary fibrosis: the ISABELA 1 and 2 randomized clinical trials
…, B Penninckx, MJ Randall, B Van Den Blink… - Jama, 2023 - jamanetwork.com
… Dr Van Den Blink reported being formerly employed by and receiving warrants (subscription
rights) from Galapagos NV. Dr Fieuw reported being employed by and receiving warrants (…
rights) from Galapagos NV. Dr Fieuw reported being employed by and receiving warrants (…
Serum biomarkers in idiopathic pulmonary fibrosis
B Van den Blink, MS Wijsenbeek… - Pulmonary pharmacology …, 2010 - Elsevier
Within the group of Idiopathic Interstitial Pneumonias (IIPs), above all Idiopathic Pulmonary
Fibrosis (IPF) poses a considerable diagnostic and therapeutic problem. Although genetic …
Fibrosis (IPF) poses a considerable diagnostic and therapeutic problem. Although genetic …