Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells

…, PL Mauri, A Monegal, M Rescigno, B Savino… - Journal of Experimental …, 2011 - rupress.org
Tumor-promoted constraints negatively affect cytotoxic T lymphocyte (CTL) trafficking to the
tumor core and, as a result, inhibit tumor killing. The production of reactive nitrogen species (…

The chemokine system in cancer biology and therapy

A Mantovani, B Savino, M Locati, L Zammataro… - Cytokine & growth factor …, 2010 - Elsevier
Chemokines are a key component of cancer-related inflammation. Chemokines and chemokine
receptors are downstream of genetic events that cause neoplastic transformation and …

The lymphatic system controls intestinal inflammation and inflammation-associated colon cancer through the chemokine decoy receptor D6

S Vetrano, EM Borroni, A Sarukhan, B Savino… - Gut, 2010 - gut.bmj.com
Background and aims Inflammatory CC chemokines have long been associated with cancer,
but unequivocal evidence of a role in clinically relevant models of carcinogenesis is lacking…

The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis

…, F Tomay, M De Pizzol, R Silva-Gomes, B Savino… - Nature …, 2019 - nature.com
The plasma membrane tetraspan molecule MS4A4A is selectively expressed by
macrophage-lineage cells, but its function is unknown. Here we report that MS4A4A was restricted to …

[HTML][HTML] ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity

M Massara, O Bonavita, B Savino, N Caronni… - Nature …, 2018 - nature.com
Atypical chemokine receptors (ACKRs) are regulators of leukocyte traffic, inflammation, and
immunity. ACKR2 is a scavenger for most inflammatory CC chemokines and is a negative …

Regulation of D6 chemokine scavenging activity by ligand-and Rab11-dependent surface up-regulation

…, A Anselmo, A Doni, B Savino… - Blood, The Journal …, 2008 - ashpublications.org
The decoy receptor D6 plays a nonredundant role in the control of inflammatory processes
through scavenging of inflammatory chemokines. However it remains unclear how it is …

Myeloid cells in cancer-related inflammation

N Caronni, B Savino, R Bonecchi - Immunobiology, 2015 - Elsevier
Myeloid cells are key elements of the cancer-related inflammation with the potential to
support not only tumor growth but also invasion and metastasis. Tumor-derived factors affect …

Role of myeloid cells in the immunosuppressive microenvironment in gliomas

…, L Passoni, D Mavilio, R Bonecchi, M Locati, B Savino - Immunobiology, 2020 - Elsevier
Glioma is the most common primary brain cancer, and half of patients present a diagnosis of
glioblastoma (GBM), its most aggressive and lethal form. Conventional therapies, including …

Chemokine decoy receptors: structure–function and biological properties

R Bonecchi, B Savino, EM Borroni, A Mantovani… - The Chemokine System …, 2010 - Springer
Chemokines induce cell migration through the activation of a distinct family of structurally
related heterotrimeric G protein-coupled receptors (GPCR). Over the last few years, several …

ERK-dependent downregulation of the atypical chemokine receptor D6 drives tumor aggressiveness in Kaposi sarcoma

B Savino, N Caronni, A Anselmo, F Pasqualini… - Cancer immunology …, 2014 - AACR
D6 is an atypical chemokine receptor acting as a decoy and scavenger for inflammatory CC
chemokines expressed in lymphatic endothelial cells. Here, we report that D6 is expressed …