The p53 tumor suppressor gene product can induce apoptotic cell death through an unknown
mechanism. Here we demonstrate that a temperature-sensitive p53 induces temperature-…

… Release date: 2020 Publisher: McGraw-Hill Education Author: Barbara L. Hoffman, John
O. Schorge, Karen D. Bradshaw, Lisa M. … Hoffman, Brian M. Casey, Catherine Y. Spong …

Gadd45a (Gadd45), Gadd45b (MyD118), and Gadd45g (CR6) constitute a family of
evolutionarily conserved, small, acidic, nuclear proteins, which have been implicated in terminal …

Recently, both Bcl-2, which promotes cell survival, and Bax, which promotes cell death,
have been implicated as major players in the control of apoptotic pathways, and it has been …

A remarkable overlap was observed between the gadd genes, a group of often coordinately
expressed genes that are induced by genotoxic stress and certain other growth arrest …

The recently cloned protein, p21 (WAF1/CIP1) is a downstream effector of p53, and mediates
growth arrest by inhibiting the action of G1 cyclin-dependent kinases. Since cellular …

Transforming growth factor-β (TGF-β)-dependent apoptosis is important in the elimination of
damaged or abnormal cells from normal tissues in vivo. In this report, we identify GADD45b …

The proto-oncogene c-myc has been shown to play a pivotal role in cell cycle regulation,
metabolism, apoptosis, differentiation, cell adhesion, and tumorigenesis, and participates in …

Gadd45 genes have been implicated in stress signaling in response to physiological or
environmental stressors, which results in cell cycle arrest, DNA repair, cell survival and …

… With this book, Barbara Hoffman has more than achieved this aim and I congratulate her …
the energetic and challenging efforts Barbara Hoffman was undertaking in connection with her …