We analyzed genome-wide association data from 1,380 Europeans with early-onset and
morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers …

Background Maternal obesity and excessive gestational weight gain may have persistent
effects on offspring fat development. However, it remains unclear whether these effects differ …

Importance Both low and high gestational weight gain have been associated with adverse
maternal and infant outcomes, but optimal gestational weight gain remains uncertain and not …

Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …

Background: Dietary factors might modify cognitive decline that results from aging. Fatty
acids, which are limiting factors in brain development, are prime candidates. Objective: We …

Type 2 diabetes mellitus results from the interaction of environmental factors with a combination
of genetic variants, most of which were hitherto unknown. A systematic search for these …

In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we
identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a …

Background Ambient air pollution has been associated with restricted fetal growth, which is
linked with adverse respiratory health in childhood. We assessed the effect of maternal …

Objective To assess the separate and combined associations of maternal pre‐pregnancy
body mass index (BMI) and gestational weight gain with the risks of pregnancy complications …

Background Preterm birth, low birth weight, and infant catch-up growth seem associated
with an increased risk of respiratory diseases in later life, but individual studies showed …