… Macrophages were allowed to adhere for 2 hours in a cell incubator, after which nonadherent
B and T cells were removed by gently washing three times with warm phosphate-buffered …

Integrin-mediated cell adhesion is necessary for endothelial cell proliferation and apoptosis,
which is a major determinant in tumor-induced angiogenesis. In this study, we compared …

… (B) G i pathway activation was monitored in HEK293 cells transfected with GPR84 and
the Gα i2 activation biosensor. Cells were co-treated with 125 mM sodium decanoate and …

… (19) Figure 1 shows a fitting (20a) of compound 34 into the binding site of the B domain
of protein A. The binding site is largely hydrophobic (green) and contains only a few sites for …

… and fitted using the Salazar–Knowles equation to determine the inspiratory capacity (parameter
A), the total lung capacity minus the volume at a pressure of zero (parameter B), and the …

… (B) There was less injury in both cortex and outer medulla in late PBI-4050–treated eNOS
–/– db/db mice compared with vehicle-treated eNOS –/– db/db mice. (C and D) Late PBI-4050 …

Hepatic fibrosis is a major cause of morbidity and mortality for which there is currently no
effective therapy. We previously showed that 2-(3-pentylphenyl)acetic acid (PBI-4050) is a dual …

… 1 00 U/mI), streptomycin (100 pg/ml), amphotericin B (0.25 pg/ml) and 15% fetal calf serum
and … fecl of LPS on +LA expie\sion by mway mouth triiiscle cellq (B) The etfccl of IL-I or1 sPLA, …

PBI-4050 (3-pentylbenzenacetic acid sodium salt), a novel first-in-class orally active compound
that has completed clinical Phases Ib and II in subjects with chronic kidney disease (CKD…

… Reagents and conditions: a) fluoroaniline, acetone/water, −10 C to RT; b) 4-(tert-… in
which a is the major tumor diameter and b is the minor perpendicular diameter. Tumors …