The mechanisms involved in the development of severe angioobliterative pulmonary arterial
hypertension (PAH) are multicellular and complex. Many of the features of human severe …

Albeit right ventricular failure (RVF) is a major complication in patients with pulmonary
arterial hypertension, the knowledge on the pathobiology of RVF is still incomplete and RV-…

In spite of treatment, severe angioproliferative pulmonary arterial hypertension (PAH)
remains a disease characterized by great morbidity and shortened survival. New treatment …

Pulmonary arterial hypertension (PAH) is a progressive and debilitating condition. Despite
promoting vasodilation, current drugs have a therapeutic window within which they are limited …

Advances in tissue fixation and imaging techniques have yielded increasing appreciation
for the glycosaminoglycan-rich endothelial glycocalyx and its in vivo manifestation, the …

The risk and progression of pulmonary vascular disease in patients with congenital heart
disease is dependent on the hemodynamics associated with different lesions. However, the …

Trichloroethylene exposure is a major risk factor for pulmonary veno-occlusive disease. We
demonstrated that trichloroethylene alters the endothelial barrier integrity, at least in part, …

Pulmonary arterial hypertension (PAH) is a rare disorder associated with high morbidity and
mortality despite currently available treatments. We compared the phosphoproteome of lung …

Lung ischemia–reperfusion injury is a common clinical concern. As the injury occurs, the
pulmonary afferent nerves play a key role in regulating respiratory functions under …

Pulmonary arterial hypertension is a fatal disease associated with pulmonary vascular
remodeling and right ventricular hypertrophy. Pre-clinical animal models that reproduce the …