The gut–lung axis in respiratory disease

BJ Marsland, A Trompette… - Annals of the American …, 2015 - atsjournals.org
Host–microorganism interactions shape local cell functionality, immune responses, and can
influence disease development. Evidence indicates that the impact of host–microbe …

[HTML][HTML] Skin barrier immunology from early life to adulthood

A Trompette, ND Ubags - Mucosal Immunology, 2023 - Elsevier
Our skin has a unique barrier function, which is imperative for the body’s protection against
external pathogens and environmental insults. Although interacting closely and sharing …

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

A Trompette, ES Gollwitzer, K Yadava, AK Sichelstiel… - Nature medicine, 2014 - nature.com
Metabolites from intestinal microbiota are key determinants of host-microbe mutualism and,
consequently, the health or disease of the intestinal tract. However, whether such host-…

Lung microbiota promotes tolerance to allergens in neonates via PD-L1

ES Gollwitzer, S Saglani, A Trompette, K Yadava… - Nature medicine, 2014 - nature.com
Epidemiological data point toward a critical period in early life during which environmental
cues can set an individual on a trajectory toward respiratory health or disease 1 , 2 , 3 , 4 , 5 , …

[PDF][PDF] Dietary fiber confers protection against flu by shaping Ly6c− patrolling monocyte hematopoiesis and CD8+ T cell metabolism

A Trompette, ES Gollwitzer, C Pattaroni… - Immunity, 2018 - cell.com
Dietary fiber protects against chronic inflammatory diseases by dampening immune responses
through short-chain fatty acids (SCFAs). Here we examined the effect of dietary fiber in …

β-Casomorphin-7 regulates the secretion and expression of gastrointestinal mucins through a μ-opioid pathway

S Zoghbi, A Trompette, J Claustre… - American Journal …, 2006 - journals.physiology.org
We have recently shown that β-casomorphin-7, a milk opioid peptide, strongly stimulates mucin
secretion in the rat jejunum through a nervous pathway and opioid receptor activation. In …

[HTML][HTML] Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation

A Trompette, J Pernot, O Perdijk, RAA Alqahtani… - Mucosal …, 2022 - Elsevier
Barrier integrity is central to the maintenance of healthy immunological homeostasis. Impaired
skin barrier function is linked with enhanced allergen sensitization and the development …

Microbiota promotes chronic pulmonary inflammation by enhancing IL-17A and autoantibodies

…, C Pattaroni, AK Sichelstiel, A Trompette… - American journal of …, 2016 - atsjournals.org
Rationale: Changes in the pulmonary microbiota are associated with progressive respiratory
diseases including chronic obstructive pulmonary disease (COPD). Whether there is a …

Effects of peptides derived from dietary proteins on mucus secretion in rat jejunum

J Claustre, F Toumi, A Trompette… - American Journal …, 2002 - journals.physiology.org
The hypothesis that dietary proteins or their hydrolysates may regulate intestinal mucin
discharge was investigated in the isolated vascularly perfused rat jejunum using an enzyme-…

Microbial metabolism of l-tyrosine protects against allergic airway inflammation

…, C Pattaroni, O Perdijk, C Yap, A Trompette… - Nature …, 2021 - nature.com
The constituents of the gut microbiome are determined by the local habitat, which itself is
shaped by immunological pressures, such as mucosal IgA. Using a mouse model of restricted …