Pulmonary artery smooth muscle cell (PA-SMC) proliferation and inflammation are key
components of pulmonary arterial hypertension (PAH). Interleukin (IL)-1β binds to IL-1 receptor (R…

Monocytes/macrophages are major effectors of lung inflammation associated with various
forms of pulmonary hypertension (PH). Interactions between the CCL2/CCR2 and CX3CL1/…

Macrophages are major players in the pathogenesis of pulmonary arterial hypertension (PAH).
To investigate whether lung macrophages and pulmonary-artery smooth muscle cells (…

Background— Pulmonary arterial hypertension (PH), whether idiopathic or related to underlying
diseases such as HIV infection, results from complex vessel remodeling involving both …

Chronic obstructive pulmonary disease (COPD) is a highly prevalent and devastating condition
for which no curative treatment is available. Exaggerated lung cell senescence may be a …

Background We aimed to determine the safety and efficacy of nintedanib, an oral anti-angiogenic
tyrosine kinase inhibitor, in combination with pembrolizumab, an anti-PD1 …

Excessive growth of pulmonary arterial (PA) smooth muscle cells (SMCs) is a major component
of PA hypertension (PAH). The calcium-activated neutral cysteine proteases calpains 1 …

Objective— Senescent pulmonary artery smooth muscle cells (PA-SMCs) may contribute to
the pathogenesis of pulmonary hypertension by producing secreted factors. The aim of this …

Background— Cells exhibiting dysregulated growth may express telomerase reverse
transcriptase (TERT), the dual function of which consists of maintaining telomere length, in …

Sequential explorations of fresh tumor biopsies demonstrated that mesothelioma resistance
to anti–PD-1 + antiangiogenics is not due to a lack of tumor T-cell infiltration but rather due …