Lipid bodies have an important role in energy storage and lipid regulation. Here we show that
lipid bodies are a major source of contrast in third-harmonic generation (THG) microscopy …

Objective: To evaluate non-atherosclerotic cardiac deaths in the UK population aged over 15
years including elderly patients and to highlight the concept of the structurally normal heart …

Estrogen receptor alpha (ERα) activation functions AF-1 and AF-2 classically mediate gene
transcription in response to estradiol (E2). A fraction of ERα is targeted to plasma membrane …

Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) is an autosomal-dominant
cancer-predisposition syndrome with a significant risk of gastric, but not colorectal, …

The organization of collagen during fibrotic processes is poorly characterized because of the
lack of appropriate methodologies. Here we show that multimodal multiphoton microscopy …

Idiopathic pulmonary fibrosis (IPF) is a devastating disease of unknown cause. Key signaling
developmental pathways are aberrantly expressed in IPF. The hedgehog pathway plays a …

Mutations in the COL2A1 gene cause a spectrum of rare autosomal‐dominant conditions
characterized by skeletal dysplasia, short stature, and sensorial defects. An early diagnosis is …

A major atheroprotective functionality of high‐density lipoproteins (HDLs) is to promote “reverse
cholesterol transport” (RCT). In this process, HDLs mediate the efflux and transport of …

Estetrol (E 4 ) is a natural estrogen with a long half‐life produced only by the human fetal
liver during pregnancy. The crystal structures of the estrogen receptor α ( ER α) ligand‐binding …

The beneficial metabolic actions of estrogen-based therapies are mainly mediated by
estrogen receptor α (ERα), a nuclear receptor that regulates gene transcription through two …