Role for miR-204 in human pulmonary arterial hypertension
A Courboulin, R Paulin, NJ Giguère… - Journal of Experimental …, 2011 - rupress.org
Pulmonary arterial hypertension (PAH) is characterized by enhanced proliferation and
reduced apoptosis of pulmonary artery smooth muscle cells (PASMCs). Because microRNAs …
reduced apoptosis of pulmonary artery smooth muscle cells (PASMCs). Because microRNAs …
Role for DNA damage signaling in pulmonary arterial hypertension
…, F Potus, S Zervopoulos, C Graydon, A Courboulin… - Circulation, 2014 - Am Heart Assoc
Background— Pulmonary arterial hypertension (PAH) is associated with sustained inflammation
known to promote DNA damage. Despite these unfavorable environmental conditions, …
known to promote DNA damage. Despite these unfavorable environmental conditions, …
Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension
R Paulin, A Courboulin, J Meloche, V Mainguy… - Circulation, 2011 - Am Heart Assoc
Background— Pulmonary artery hypertension (PAH) is a proliferative disorder associated
with enhanced pulmonary artery smooth muscle cell proliferation and suppressed apoptosis. …
with enhanced pulmonary artery smooth muscle cell proliferation and suppressed apoptosis. …
Dehydroepiandrosterone inhibits the Src/STAT3 constitutive activation in pulmonary arterial hypertension
…, MH Jacob, M Bisserier, A Courboulin… - American Journal …, 2011 - journals.physiology.org
Pulmonary arterial hypertension (PAH) is an obstructive vasculopathy characterized by
enhanced pulmonary artery smooth muscle cell (PASMC) proliferation and suppressed apoptosis…
enhanced pulmonary artery smooth muscle cell (PASMC) proliferation and suppressed apoptosis…
[HTML][HTML] Krüppel-like factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension
A Courboulin, VL Tremblay, M Barrier, J Meloche… - Respiratory …, 2011 - Springer
Background Pulmonary arterial hypertension (PAH) is a vascular remodeling disease
characterized by enhanced proliferation of pulmonary artery smooth muscle cell (PASMC) and …
characterized by enhanced proliferation of pulmonary artery smooth muscle cell (PASMC) and …
Role for runt-related transcription factor 2 in proliferative and calcified vascular lesions in pulmonary arterial hypertension
…, S Chabot, VF Tanguay, A Courboulin… - American journal of …, 2016 - atsjournals.org
Rationale: Pulmonary arterial hypertension (PAH) is characterized by excessive proliferation
of pulmonary artery smooth muscle cells (PASMCs). This is sustained in time by the down-…
of pulmonary artery smooth muscle cells (PASMCs). This is sustained in time by the down-…
NMDA-type glutamate receptor activation promotes vascular remodeling and pulmonary arterial hypertension
SJ Dumas, G Bru-Mercier, A Courboulin… - Circulation, 2018 - Am Heart Assoc
Background: Excessive proliferation and apoptosis resistance in pulmonary vascular cells
underlie vascular remodeling in pulmonary arterial hypertension (PAH). Specific treatments …
underlie vascular remodeling in pulmonary arterial hypertension (PAH). Specific treatments …
RAGE-dependent activation of the oncoprotein Pim1 plays a critical role in systemic vascular remodeling processes
J Meloche, R Paulin, A Courboulin… - … , and vascular biology, 2011 - Am Heart Assoc
Objective— Vascular remodeling diseases (VRD) are mainly characterized by inflammation
and a vascular smooth muscle cells (VSMCs) proproliferative and anti-apoptotic phenotype. …
and a vascular smooth muscle cells (VSMCs) proproliferative and anti-apoptotic phenotype. …
Plumbagin reverses proliferation and resistance to apoptosis in experimental PAH
A Courboulin, M Barrier, T Perreault… - European …, 2012 - Eur Respiratory Soc
Like cancer, pulmonary arterial hypertension (PAH) is characterised by a pro-proliferative
and anti-apoptotic phenotype. In PAH, pulmonary artery smooth muscle cell (PASMC) …
and anti-apoptotic phenotype. In PAH, pulmonary artery smooth muscle cell (PASMC) …
Targeting cell motility in pulmonary arterial hypertension
R Paulin, J Meloche, A Courboulin… - European …, 2014 - Eur Respiratory Soc
Pulmonary artery smooth muscle cells (PASMC), in pulmonary arterial hypertension (PAH),
contribute to obliterative vascular remodelling and are characterised by enhanced …
contribute to obliterative vascular remodelling and are characterised by enhanced …