User profiles for Athanassios Fragoulis

Athanassios Fragoulis

Uniklinik RWTH Aachen
Verified email at ukaachen.de
Cited by 1930

Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice

CJ Wruck, A Fragoulis, A Gurzynski… - Annals of the …, 2011 - ard.bmj.com
Objectives Increasing evidence suggests that oxidative stress may play a key role in joint
destruction due to rheumatoid arthritis (RA). The aim of this study was to elucidate the role of …

Nrf2 in health and disease: current and future clinical implications

O Al-Sawaf, T Clarner, A Fragoulis, YW Kan… - Clinical …, 2015 - portlandpress.com
The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is a major regulator
of oxidative stress defence in the human body. As Nrf2 regulates the expression of a large …

[HTML][HTML] Widespread post-transcriptional attenuation of genomic copy-number variation in cancer

E Gonçalves, A Fragoulis, L Garcia-Alonso, T Cramer… - Cell systems, 2017 - cell.com
Copy-number variations (CNVs) are ubiquitous in cancer and often act as driver events, but
the effects of CNVs on the proteome of tumors are poorly understood. Here, we analyze …

[HTML][HTML] Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsia

N Kweider, A Fragoulis, C Rosen, U Pecks… - Journal of Biological …, 2011 - ASBMB
Several recently published studies have suggested that decreasing VEGF levels result in
placental oxidative stress in preeclampsia, although the question as to how decreased VEGF …

The cancer stem cell subtype determines immune infiltration of glioblastoma

…, MJ Riemenschneider, A Fragoulis… - Stem cells and …, 2012 - liebertpub.com
Immune cell infiltration varies widely between different glioblastomas (GBMs). The
underlying mechanism, however, remains unknown. Here we show that TGF-beta regulates …

[HTML][HTML] Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease

A Fragoulis, S Siegl, M Fendt, S Jansen, U Soppa… - Redox biology, 2017 - Elsevier
Introduction There is increasing evidence for the involvement of chronic inflammation and
oxidative stress in the pathogenesis of Alzheimer's disease (AD). Nuclear factor erythroid 2-…

[HTML][HTML] Astrocytic Nrf2 expression protects spinal cord from oxidative stress following spinal cord injury in a male mouse model

…, C Voelz, V Behrens, C Beyer, A Fragoulis… - Journal of …, 2022 - Springer
Background Spinal cord injury (SCI) induces a multitude of deleterious processes, including
neuroinflammation and oxidative stress (OS) which contributed to neuronal damage and …

Role of Nrf2 in fracture healing: clinical aspects of oxidative stress

Y Kubo, CJ Wruck, A Fragoulis, W Drescher… - Calcified tissue …, 2019 - Springer
Fracture healing is a natural process that recapitulates embryonic skeletal development. In
the early phase after fracture, reactive oxygen species (ROS) are produced under …

Nrf2 augments skeletal muscle regeneration after ischaemia–reperfusion injury

O Al‐Sawaf, A Fragoulis, C Rosen… - The Journal of …, 2014 - Wiley Online Library
Skeletal muscles harbour a resident population of stem cells, termed satellite cells ( SCs ).
After trauma, SCs leave their quiescent state to enter the cell cycle and undergo multiple …

Siponimod ameliorates metabolic oligodendrocyte injury via the sphingosine-1 phosphate receptor 5

…, D Atanasova, T Clarner, A Fragoulis… - Proceedings of the …, 2022 - National Acad Sciences
Multiple sclerosis (MS), an autoimmune-driven, inflammatory demyelinating disease of the
central nervous system (CNS), causes irreversible accumulation of neurological deficits to a …