User profiles for Athanassios Fragoulis
Athanassios FragoulisUniklinik RWTH Aachen Verified email at ukaachen.de Cited by 1930 |
Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice
CJ Wruck, A Fragoulis, A Gurzynski… - Annals of the …, 2011 - ard.bmj.com
Objectives Increasing evidence suggests that oxidative stress may play a key role in joint
destruction due to rheumatoid arthritis (RA). The aim of this study was to elucidate the role of …
destruction due to rheumatoid arthritis (RA). The aim of this study was to elucidate the role of …
Nrf2 in health and disease: current and future clinical implications
O Al-Sawaf, T Clarner, A Fragoulis, YW Kan… - Clinical …, 2015 - portlandpress.com
The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is a major regulator
of oxidative stress defence in the human body. As Nrf2 regulates the expression of a large …
of oxidative stress defence in the human body. As Nrf2 regulates the expression of a large …
[HTML][HTML] Widespread post-transcriptional attenuation of genomic copy-number variation in cancer
Copy-number variations (CNVs) are ubiquitous in cancer and often act as driver events, but
the effects of CNVs on the proteome of tumors are poorly understood. Here, we analyze …
the effects of CNVs on the proteome of tumors are poorly understood. Here, we analyze …
[HTML][HTML] Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsia
N Kweider, A Fragoulis, C Rosen, U Pecks… - Journal of Biological …, 2011 - ASBMB
Several recently published studies have suggested that decreasing VEGF levels result in
placental oxidative stress in preeclampsia, although the question as to how decreased VEGF …
placental oxidative stress in preeclampsia, although the question as to how decreased VEGF …
The cancer stem cell subtype determines immune infiltration of glioblastoma
…, MJ Riemenschneider, A Fragoulis… - Stem cells and …, 2012 - liebertpub.com
Immune cell infiltration varies widely between different glioblastomas (GBMs). The
underlying mechanism, however, remains unknown. Here we show that TGF-beta regulates …
underlying mechanism, however, remains unknown. Here we show that TGF-beta regulates …
[HTML][HTML] Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease
A Fragoulis, S Siegl, M Fendt, S Jansen, U Soppa… - Redox biology, 2017 - Elsevier
Introduction There is increasing evidence for the involvement of chronic inflammation and
oxidative stress in the pathogenesis of Alzheimer's disease (AD). Nuclear factor erythroid 2-…
oxidative stress in the pathogenesis of Alzheimer's disease (AD). Nuclear factor erythroid 2-…
[HTML][HTML] Astrocytic Nrf2 expression protects spinal cord from oxidative stress following spinal cord injury in a male mouse model
…, C Voelz, V Behrens, C Beyer, A Fragoulis… - Journal of …, 2022 - Springer
Background Spinal cord injury (SCI) induces a multitude of deleterious processes, including
neuroinflammation and oxidative stress (OS) which contributed to neuronal damage and …
neuroinflammation and oxidative stress (OS) which contributed to neuronal damage and …
Role of Nrf2 in fracture healing: clinical aspects of oxidative stress
Fracture healing is a natural process that recapitulates embryonic skeletal development. In
the early phase after fracture, reactive oxygen species (ROS) are produced under …
the early phase after fracture, reactive oxygen species (ROS) are produced under …
Nrf2 augments skeletal muscle regeneration after ischaemia–reperfusion injury
O Al‐Sawaf, A Fragoulis, C Rosen… - The Journal of …, 2014 - Wiley Online Library
Skeletal muscles harbour a resident population of stem cells, termed satellite cells ( SCs ).
After trauma, SCs leave their quiescent state to enter the cell cycle and undergo multiple …
After trauma, SCs leave their quiescent state to enter the cell cycle and undergo multiple …
Siponimod ameliorates metabolic oligodendrocyte injury via the sphingosine-1 phosphate receptor 5
…, D Atanasova, T Clarner, A Fragoulis… - Proceedings of the …, 2022 - National Acad Sciences
Multiple sclerosis (MS), an autoimmune-driven, inflammatory demyelinating disease of the
central nervous system (CNS), causes irreversible accumulation of neurological deficits to a …
central nervous system (CNS), causes irreversible accumulation of neurological deficits to a …