The “hard wiring” encoded within the genome that determines the emergence of the
laryngotracheal groove and subsequently early lung branching morphogenesis is mediated by …

In this review we describe how mouse embryonic mammogenesis depends on a continuous
communication between the epithelial and mesenchymal compartment of the mammary …

The mammary gland undergoes a morphogenetic program during embryogenesis and puberty
that leads to the development of hollow ductal system terminating in acinar units. It later …

Epithelial cells require attachment to extracellular matrix (ECM) to suppress an apoptotic
cell death program termed anoikis. Here we describe a nonapoptotic cell death program in …

The mouse develops five pairs of mammary glands that arise during mid-gestation from five
pairs of placodes of ectodermal origin. We have investigated the molecular mechanisms of …

The adult, virgin mammary gland is a highly organized tree-like structure formed by ducts
with hollowed lumen. Although lumen formation during pubertal development appears to …

Experimental evidence is rapidly emerging that the coupling of positive regulatory signals
with the induction of negative feedback modulators is a mechanism of fine regulation in …

Lineage formation in the lung mesenchyme is poorly understood. Using a transgenic mouse
line expressing LacZ under the control of Fgf10 regulatory sequences, we show that the …

The key role played by Fgf10 during early lung development is clearly illustrated in Fgf10
knockout mice, which exhibit lung agenesis. However, Fgf10 is continuously expressed …

Idiopathic pulmonary fibrosis (IPF) is a devastating disease of unknown cause. Key signaling
developmental pathways are aberrantly expressed in IPF. The hedgehog pathway plays a …