[PDF][PDF] Microbiotas from humans with inflammatory bowel disease alter the balance of gut Th17 and RORγt+ regulatory T cells and exacerbate colitis in mice

…, SR Llewellyn, R Ng, Z Li, A Mortha, M Merad, A Das… - Immunity, 2019 - cell.com
Microbiota are thought to influence the development and progression of inflammatory bowel
disease (IBD), but determining generalizable effects of microbiota on IBD etiology requires …

Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop …

MN Ajuebor, AM Das, L Virág, RJ Flower… - The Journal of …, 1999 - journals.aai.org
The roles played by resident macrophages (Mφ) and mast cells (MCs) in polymorphonuclear
leukocyte (PMN) accumulation and chemokine production within the mouse peritoneal …

The role of CCL12 in the recruitment of fibrocytes and lung fibrosis

BB Moore, L Murray, A Das, CA Wilke… - American journal of …, 2006 - atsjournals.org
We have previously shown that mice that are genetically deficient in the CCR2 gene (CCR2−/−
mice) are protected from fluorescein isothiocyanate (FITC)-induced lung fibrosis. …

A functional genomics predictive network model identifies regulators of inflammatory bowel disease

…, A Kasarskis, C Brodmerkel, M Curran, A Das… - Nature …, 2017 - nature.com
A major challenge in inflammatory bowel disease (IBD) is the integration of diverse IBD data
sets to construct predictive models of IBD. We present a predictive model of the immune …

[HTML][HTML] Long-term activation of TLR3 by poly (I: C) induces inflammation and impairs lung function in mice

…, DE Griswold, RT Sarisky, ML Mbow, AM Das - Respiratory …, 2009 - Springer
Background The immune mechanisms associated with infection-induced disease
exacerbations in asthma and COPD are not fully understood. Toll-like receptor (TLR) 3 has an …

Anti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodeling

…, E Emmell, J Giles-Komar, X Shang, J Li, AM Das… - Cytokine, 2004 - Elsevier
Asthma is a chronic inflammatory disease characterized by reversible bronchial constriction,
pulmonary inflammation and airway remodeling. Current standard therapies for asthma …

Hyper-responsiveness of IPF/UIP fibroblasts: interplay between TGFβ1, IL-13 and CCL2

…, K Cochlin, HL Evanoff, CM Hogaboam, AM Das - The international journal …, 2008 - Elsevier
One of the hallmarks of idiopathic pulmonary fibrosis with a usual interstitial pneumonia
histological pathology (IPF/UIP) is excess collagen deposition, due to enhanced fibroblast …

Preclinical target validation using patient-derived cells

…, CL Carpenter, AJ Carr, K Clark, AM Das… - Nature Reviews Drug …, 2015 - nature.com
Abstract The Structural Genomics Consortium (SGC) and its clinical, industry and disease-
foundation partners are launching open-source preclinical translational medicine studies.

[HTML][HTML] Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages

…, AJ Hartigan, WG Finn, SL Kunkel, KE Duffy, A Das… - BMC immunology, 2010 - Springer
Background Interleukin-33 is a member of the IL-1 cytokine family whose functions are
mediated and modulated by the ST2 receptor. IL-33-ST2 expression and interactions have been …

Pulmonary epithelium is a prominent source of proteinase-activated receptor-1–inducible CCL2 in pulmonary fibrosis

…, DCJ Howell, RJ McAnulty, A Das… - American journal of …, 2009 - atsjournals.org
Rationale: Studies in patients and experimental animals provide compelling evidence of the
involvement of the major thrombin receptor, proteinase-activated receptor-1 (PAR 1 ), and …