Airway remodelling and emphysema are major structural abnormalities in chronic obstructive
pulmonary disease (COPD). In addition, pulmonary vascular remodelling may occur and …

Airway remodelling, characterised by increased airway smooth muscle (ASM) mass, subepithelial
fibrosis, goblet cell hyperplasia and mucus gland hypertrophy, is a feature of chronic …

Rationale: In a guinea pig model of allergic asthma, using perfused tracheal preparations ex
vivo, we demonstrated that l-arginine limitation due to increased arginase activity underlies …

Airway inflammation and remodeling are major features of chronic obstructive pulmonary
disease (COPD), whereas pulmonary hypertension is a common comorbidity associated with a …

To investigate mechanisms underlying allergen-induced asthmatic reactions, airway
hyperresponsiveness and remodeling, we have developed a guinea pig model of acute and …

The direct relationship between pulmonary structural changes and airway hyperresponsiveness
(AHR) in chronic obstructive pulmonary disease (COPD) is unclear. We investigated …

Recently, we have shown that allergen-induced airway hyperresponsiveness (AHR) after the
early (EAR) and late (LAR) asthmatic reaction in guinea pigs could be reversed acutely by …

Background In guinea pigs, we have previously demonstrated that the contribution of Rho-kinase
to airway responsiveness in vivo and ex vivo is enhanced after active sensitization with …

Using a guinea pig model of acute allergic asthma, we recently established that a deficiency
of nitric oxide (NO) contributes to airway hyperreactivity (AHR) after the early asthmatic …

Currently, little is known about mechanisms underlying passive sensitization-induced nonspecific
airway hyperresponsiveness. We sought to determine whether the nonspecific airway …