Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials

…, CP Vellano, P Jones, CJ Heijnen, A Kavelaars… - Nature medicine, 2023 - nature.com
Although targeting oxidative phosphorylation (OXPHOS) is a rational anticancer strategy,
clinical benefit with OXPHOS inhibitors has yet to be achieved. Here we advanced IACS-…

[HTML][HTML] Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss

…, BAJ Roelen, S Quenby, EW Kuijk, A Kavelaars… - PloS one, 2010 - journals.plos.org
Background Recurrent pregnancy loss (RPL), defined as 3 or more consecutive miscarriages,
is widely attributed either to repeated chromosomal instability in the conceptus or to …

[HTML][HTML] Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation

…, BAJ Roelen, S Quenby, EW Kuijk, A Kavelaars… - PloS one, 2010 - journals.plos.org
Background Pregnancy is widely viewed as dependent upon an intimate dialogue, mediated
by locally secreted factors between a developmentally competent embryo and a receptive …

The neuroimmune basis of fatigue

R Dantzer, CJ Heijnen, A Kavelaars, S Laye… - Trends in …, 2014 - cell.com
The exact nature and pathophysiology of fatigue remain largely elusive despite its high
prevalence in physically ill patients. Studies on the relationship between the immune system and …

Endometrial secretion analysis identifies a cytokine profile predictive of pregnancy in IVF

CM Boomsma, A Kavelaars, MJC Eijkemans… - Human …, 2009 - academic.oup.com
BACKGROUND The study of human endometrial–embryonic interactions is complicated by
the disruptive impact of endometrial sample collection on the process of implantation itself. …

Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration

CTJ van Velthoven, A Kavelaars, F van Bel… - Brain, behavior, and …, 2010 - Elsevier
Birth asphyxia is a frequent cause of perinatal morbidity and mortality and treatment options
are very limited. Our aim was to determine the effects of treatment with bone marrow-derived …

[HTML][HTML] Dorsal root ganglion infiltration by macrophages contributes to paclitaxel chemotherapy-induced peripheral neuropathy

H Zhang, Y Li, M de Carvalho-Barbosa, A Kavelaars… - The journal of pain, 2016 - Elsevier
Chemotherapy-induced peripheral neuropathy (CIPN) is a disruptive and persistent side
effect of cancer treatment with paclitaxel. Recent reports showed that paclitaxel treatment …

Activation of microglial N‐methyl‐D‐aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain

…, L Issa, F Rene, JP Loeffler, A Kavelaars… - Annals of …, 2012 - Wiley Online Library
Objective: Activated microglia play a central role in the inflammatory and excitotoxic component
of various acute and chronic neurological disorders. However, the mechanisms leading …

Extent of bilateral neuronal network reorganization and functional recovery in relation to stroke severity

…, K van der Marel, CH Nijboer, A Kavelaars… - Journal of …, 2012 - Soc Neuroscience
Remodeling of neuronal structures and networks is believed to significantly contribute to (partial)
restoration of functions after stroke. However, it has been unclear to what extent the …

[HTML][HTML] Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high-and low-quality human embryos

CHE Weimar, A Kavelaars, JJ Brosens, B Gellersen… - PloS one, 2012 - journals.plos.org
Background The aetiology of recurrent miscarriage (RM) remains largely unexplained.
Women with RM have a shorter time to pregnancy interval than normally fertile women, which …