Phase I study of GSK461364, a specific and competitive Polo-like kinase 1 inhibitor, in patients with advanced solid malignancies
…, R Sharma, AT Brunetto, TA Yap, AB Taegtmeyer… - Clinical cancer …, 2011 - AACR
Purpose: GSK461364 is an ATP-competitive inhibitor of polo-like kinase 1 (Plk1). A phase I
study of two schedules of intravenous GSK461364 was conducted. Experimental Design: …
study of two schedules of intravenous GSK461364 was conducted. Experimental Design: …
Simvastatin as a treatment for pulmonary hypertension trial
…, W Bradlow, J Wharton, A Taegtmeyer… - American journal of …, 2010 - atsjournals.org
Rationale: In animal models of pulmonary hypertension, simvastatin has been shown to
reduce pulmonary artery pressure and induce regression of associated right ventricular (RV) …
reduce pulmonary artery pressure and induce regression of associated right ventricular (RV) …
Physicians' ability to predict patients' adherence to antihypertensive medication in primary care
A Zeller, A Taegtmeyer, B Martina, E Battegay… - Hypertension …, 2008 - nature.com
Addressing adherence to medication is essential and notoriously difficult. The purpose of this
study was to determine physicians' ability to predict patients' adherence to antihypertensive …
study was to determine physicians' ability to predict patients' adherence to antihypertensive …
CC chemokine receptor 5 gene variants in relation to lung disease in sarcoidosis
…, JC Grutters, A Abdallah, A Taegtmeyer… - American journal of …, 2005 - atsjournals.org
Rationale: Genetic factors are likely to influence the clinical course and pattern of sarcoidosis,
a granulomatous disease of unknown origin. Objectives: We tested this hypothesis for CC …
a granulomatous disease of unknown origin. Objectives: We tested this hypothesis for CC …
Leucopenia associated with metamizole: a case-control study
…, A Zeller, S Krähenbühl, AB Taegtmeyer - Swiss medical …, 2017 - smw.ch
AIMS OF THE STUDY: The aim of this study was to identify possible risk factors for the
development of leucopenia associated with metamizole use. METHODS: A retrospective case-…
development of leucopenia associated with metamizole use. METHODS: A retrospective case-…
Drug-related problems and factors influencing acceptance of clinical pharmacologistsalerts in a large cohort of neurology inpatients.
AB Taegtmeyer, I Curkovic, N Corti, C Rosen… - Swiss medical …, 2012 - zora.uzh.ch
QUESTIONS UNDER STUDY/PRINCIPLES: Data regarding the prevalence and types of
drug-related problems (DRPs) among neurology inpatients is sparse. The objective of this study …
drug-related problems (DRPs) among neurology inpatients is sparse. The objective of this study …
[HTML][HTML] A study of the relationship between serum bile acids and propranolol pharmacokinetics and pharmacodynamics in patients with liver cirrhosis and in healthy …
AB Taegtmeyer, M Haschke, L Tchambaz, M Buylaert… - PloS one, 2014 - journals.plos.org
The main objectives of the study were to determine the exposure and bioavailability of oral
propranolol and to investigate their associations with serum bile acid concentration in …
propranolol and to investigate their associations with serum bile acid concentration in …
[HTML][HTML] AMP Deaminase 1 Gene Polymorphism and Heart Disease—A Genetic Association That Highlights New Treatment
…, P Romaszko, M Zabielska, A Taegtmeyer… - … drugs and therapy, 2014 - Springer
Nucleotide metabolism and signalling is directly linked to myocardial function. Therefore
analysis how diversity of genes coding nucleotide metabolism related proteins affects clinical …
analysis how diversity of genes coding nucleotide metabolism related proteins affects clinical …
Impact of history of heart failure on diagnostic and prognostic value of BNP: results from the B-type Natriuretic Peptide for Acute Shortness of Breath Evaluation …
…, M Potocki, T Reichlin, A Taegtmeyer… - International journal of …, 2010 - Elsevier
OBJECTIVES: This study aimed to examine the influence of history of heart failure (HF) on
circulating levels, diagnostic accuracy and prognostic value of B-type natriuretic peptide (BNP…
circulating levels, diagnostic accuracy and prognostic value of B-type natriuretic peptide (BNP…
Toxicity of clopidogrel and ticlopidine on human myeloid progenitor cells: importance of metabolites
S Maseneni, M Donzelli, AB Taegtmeyer, K Brecht… - Toxicology, 2012 - Elsevier
Ticlopidine and clopidogrel are thienopyridine derivatives used for inhibition of platelet
aggregation. Not only hepatotoxicity, but also bone marrow toxicity may limit their use. Aims of the …
aggregation. Not only hepatotoxicity, but also bone marrow toxicity may limit their use. Aims of the …