Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind …

…, F De La Portilla, E Goldin, MP Richard, A Leselbaum… - The Lancet, 2016 - thelancet.com
Background Complex perianal fistulas in Crohn's disease are challenging to treat. Allogeneic,
expanded, adipose-derived stem cells (Cx601) are a promising new therapeutic approach…

Long-term efficacy and safety of stem cell therapy (Cx601) for complex perianal fistulas in patients with Crohn's disease

…, MP Richard, MC Diez, I Tagarro, A Leselbaum… - Gastroenterology, 2018 - Elsevier
Background & Aims Therapies for perianal fistulas in patients with Crohn’s disease are
often ineffective in producing long-term healing. We performed a randomized placebo-controlled …

[HTML][HTML] Efficacy and safety of aclidinium bromide/formoterol fumarate fixed-dose combinations compared with individual components and placebo in patients with …

…, E Molins, C Caracta, EG Gil, A Leselbaum - BMC pulmonary …, 2014 - Springer
Background Aclidinium/formoterol is a twice-daily (BID) fixed-dose combination (FDC) in
development for chronic obstructive pulmonary disease (COPD). The efficacy and safety of …

[HTML][HTML] Efficacy and safety of fixed-dose combinations of aclidinium bromide/formoterol fumarate: the 24-week, randomized, placebo-controlled AUGMENT COPD …

…, SI Rennard, EM Kerwin, V Mergel, AR Leselbaum… - Respiratory …, 2014 - Springer
Background Combining two long-acting bronchodilators with complementary mechanisms
of action may provide treatment benefits to patients with chronic obstructive pulmonary …

[HTML][HTML] Safety, immunogenicity and effect on viral rebound of HTI vaccines in early treated HIV-1 infection: a randomized, placebo-controlled phase 1 trial

, … 1 Geleziunas Romas 9 Leselbaum Anne R. 7 Loste … - Nature Medicine, 2022 - nature.com
HIVACAT T-cell immunogen (HTI) is a novel human immunodeficiency virus (HIV) vaccine
immunogen designed to elicit cellular immune responses to HIV targets associated with viral …

[HTML][HTML] Aclidinium bromide and formoterol fumarate as a fixed-dose combination in COPD: pooled analysis of symptoms and exacerbations from two six-month …

…, D Singh, AD D'Urzo, E Molins, A Leselbaum… - Respiratory …, 2015 - Springer
Background The combination of aclidinium bromide, a long-acting anticholinergic, and formoterol
fumarate, a long-acting beta 2 -agonist (400/12 μg twice daily) achieves improvements …

Efficacy and safety of aclidinium/formoterol versus salmeterol/fluticasone: a phase 3 COPD study

…, B Seoane, RM Segarra, A Leselbaum - European …, 2016 - Eur Respiratory Soc
The efficacy and safety of twice-daily aclidinium bromide/formoterol fumarate was compared
with that of salmeterol/fluticasone propionate in patients with stable, moderate-to-severe …

[HTML][HTML] A randomised double-blind, placebo-controlled, long-term extension study of the efficacy, safety and tolerability of fixed-dose combinations of aclidinium …

…, JF Donohue, A Lei, E Molins, A Leselbaum - Respiratory …, 2017 - Elsevier
Introduction Aclidinium bromide/formoterol fumarate (AB/FF) 400/12 μg efficacy and safety
was demonstrated in two 6-month Phase III studies (AUGMENT and ACLIFORM) and a 12-…

Efficacy and tolerability of the long-acting somatostatin analog lanreotide in acromegaly. A 12-month multicenter study of 58 acromegalic patients

P Chanson, A Leselbaum, J Blumberg, G Schaison - Pituitary, 2000 - Springer
Objective: To determine the effects of the new somatostatin analogue, lanreotide, in its prolonged
released form (PR), in patients with acromegaly. Design: Prospective open multicenter …

A placebo-controlled ATI trial of HTI vaccines in early treated HIV infection

…, P Coll, À Rivero, AR Leselbaum… - Topics in Antiviral …, 2021 - pesquisa.bvsalud.org
Background: HTI is a novel HIV vaccine immunogen designed at redirecting cellular immune
responses to HIV targets associated with viral control. Methods: The AELIX-002 trial (…