Designing CXCL8-based decoy proteins with strong anti-inflammatory activity in vivo

A Falsone, V Wabitsch, E Geretti, H Potzinger… - Bioscience …, 2013 - portlandpress.com
IL (interleukin)-8 [CXCL8 (CXC chemokine ligand 8)] exerts its role in inflammation by
triggering neutrophils via its specific GPCRs (G-protein-coupled receptors), CXCR1 (CXC …

[HTML][HTML] A combinatorial approach to biophysically characterise chemokine-glycan binding affinities for drug development

…, D Jeremic, T Fuchs, M Gschwandtner, A Falsone… - Molecules, 2014 - mdpi.com
Chemokine binding to glycosaminoglycans (GAGs) is recognised to be an important step in
inflammation and other pathological disorders like tumor growth and metastasis. Although …

Structure‐based design of decoy chemokines as a way to explore the pharmacological potential of glycosaminoglycans

T Adage, AM Piccinini, A Falsone… - British journal of …, 2012 - Wiley Online Library
Glycosaminoglycans (GAGs) are a class of highly negatively charged, unbranched, O‐linked
polysaccharides that are involved in many diseases. Their role as a protein‐binding matrix …

[HTML][HTML] Legal but lethal: functional protein aggregation at the verge of toxicity

A Falsone, SF Falsone - Frontiers in cellular neuroscience, 2015 - frontiersin.org
Many neurodegenerative disorders are linked to irreversible protein aggregation, a process
that usually comes along with toxicity and serious cellular damage. However, it is emerging …

Pa401, a novel decoy Cxcl8-based biologic therapeutic reduces lung inflammation induced by LPS as well as plasma inflammatory markers in mice

…, R Doornbos, C Zankl, A Falsone… - C31. REGULATION …, 2012 - atsjournals.org
Methods: Mice aerosolized with LPS and treated with vehicle were used for comparison.
Terminal blood samples were collected at t= 0, 5, 15, 30, 60 and 240min for plasma analysis of …

PK/PD profiles of the CXCL8 decoy protein PA401 after intravenous and intratracheal administration in saline and LPS exposed mice

T Adage, A Falsone, R Doornbos, M Bartley, A Kungl - 2012 - Eur Respiratory Soc
Neutrophils play a crucial role in acute and chronic lung diseases including ALI, COPD, CF
and severe asthma, and their presence in the lung has been correlated to disease severity …

Designing CXCL8-based decoy proteins with strong anti-inflammatory activity in vivo

M Teixeira, J Kungl, T Adage, A Falsone, V Wabitsch… - 2013 - agris.fao.org
IL (interleukin)-8 [CXCL8 (CXC chemokine ligand 8)] exerts its role in inflammation by
triggering neutrophils via its specific GPCRs (G-protein-coupled receptors), CXCR1 (CXC …

[HTML][HTML] The molecular chaperone Hsp90 modulates intermediate steps of amyloid assembly of the Parkinson-related protein α-synuclein

SF Falsone, AJ Kungl, A Rek, R Cappai… - Journal of biological …, 2009 - ASBMB
α-Synuclein is an intrinsically unstructured protein that binds to membranes, forms fibrils, and
is involved in neurodegeneration. We used a reconstituted in vitro system to show that the …

A proteomic approach towards the Hsp90‐dependent ubiquitinylated proteome

SF Falsone, B Gesslbauer, A Rek, AJ Kungl - Proteomics, 2007 - Wiley Online Library
Since many Hsp90 client proteins are key players in tumour pathways, the ubiquitylation
and subsequent degradation of Hsp90‐substrates as a consequence of pharmacologically …

[HTML][HTML] A proteomic snapshot of the human heat shock protein 90 interactome

SF Falsone, B Gesslbauer, F Tirk, AM Piccinini… - FEBS letters, 2005 - Elsevier
… Fabio Falsone , Bernd Gesslbauer , Florian Tirk , Anna-Maria Piccinini , Andreas J. Kungl …
We thank Angelika Rek for fruitful discussions. … SF Falsone, S. Leptihn, A. Osterauer, M. …