TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes

…, K Hardes, J Koepke, L Schulte, AR Koczulla… - Journal of …, 2019 - Am Soc Microbiol
Cleavage of influenza virus hemagglutinin (HA) by host cell proteases is essential for virus
infectivity and spread. We previously demonstrated in vitro that the transmembrane protease …

[HTML][HTML] Benefits of whole body vibration training in patients hospitalised for COPD exacerbations-a randomized clinical trial

…, S Janciauskiene, C Vogelmeier, AR Koczulla - BMC pulmonary …, 2014 - Springer
Background Patients with stable COPD show improvements in exercise capacity and muscular
function after the application of whole body vibration. We aimed to evaluate whether this …

The prevalence of diagnosed α1-antitrypsin deficiency and its comorbidities: results from a large population-based database

…, S Janciauskiene, AR Koczulla… - European …, 2017 - Eur Respiratory Soc
α 1 -Antitrypsin deficiency (AATD) is a genetically determined disorder that is associated
with different clinical manifestations. We aimed to assess the prevalence of diagnosed AATD …

[HTML][HTML] Prevalence of comorbidities in COPD patients by disease severity in a German population

T Greulich, BJD Weist, AR Koczulla… - Respiratory …, 2017 - Elsevier
Chronic obstructive pulmonary disease (COPD) is commonly associated with multiple
comorbidities. Our objective was to assess the prevalence of comorbidities in patients with COPD …

Discrimination between COPD patients with and without alpha 1‐antitrypsin deficiency using an electronic nose

…, T Greulich, S Noeske, R Bals, AR Koczulla - …, 2011 - Wiley Online Library
Background and objective: To compare the volatile organic compound patterns of patients
with COPD with and without alpha 1‐antitrypsin (AAT) deficiency using electronic nose …

[HTML][HTML] Measuring compounds in exhaled air to detect Alzheimer's disease and Parkinson's disease

…, C Vogelmeier, R Dodel, AR Koczulla - PloS one, 2015 - journals.plos.org
Background Alzheimer’s disease (AD) is diagnosed based upon medical history, neuropsychiatric
examination, cerebrospinal fluid analysis, extensive laboratory analyses and cerebral …

[HTML][HTML] α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

…, SN Kaiser, A Slowik, C Beyer, AR Koczulla… - Journal of …, 2018 - Springer
Background Neuroinflammation has an essential impact on the pathogenesis and progression
of Alzheimer’s disease (AD). Mostly mediated by microglia and astrocytes, inflammatory …

Detection of obstructive sleep apnoea by an electronic nose

…, CF Vogelmeier, U Köhler, AR Koczulla - European …, 2013 - Eur Respiratory Soc
Diagnosis of obstructive sleep apnoea syndrome (OSAS) is technically demanding, cost-intensive
and time-consuming. The measurement of volatile organic compounds by an …

The distribution of alpha-1 antitrypsin genotypes between patients with COPD/emphysema, asthma and bronchiectasis

…, S Wilhelm, R Bals, AR Koczulla… - … Journal of Chronic …, 2020 - Taylor & Francis
Purpose Alpha-1-antitrypsin deficiency (AATD) is a rare hereditary condition characterized
by low circulating levels of alpha-1antitrypsin (AAT). While the association between AATD …

[HTML][HTML] Results from a large targeted screening program for alpha-1-antitrypsin deficiency: 2003-2015

…, S Wiedmann, M Wencker, R Bals, AR Koczulla - Orphanet journal of rare …, 2016 - Springer
Background Alpha-1-antitrypsin deficiency (AATD) is an autosomal codominant inherited
disease that is significantly underdiagnosed. We have previously shown that the combination …